Gastric cancer (GC) is a complex and heterogeneous disease with significant phenotypic
and genetic variation. Traditional classification systems rely mainly on the evaluation of …

Many tumors have well-defined vulnerabilities, thus potentially allowing highly specific and
effective treatment. There is a spectrum of actionable genetic alterations which are shared …

Cancers of the digestive system are major contributors to global cancer-associated morbidity
and mortality, accounting for 35% of annual cases of cancer deaths. The etiologies …

Targeted therapy is crucial for advanced colorectal cancer (CRC) positive for genetic drivers.
With advances in deep sequencing technology and new targeted drugs, existing standard …

Deficient mismatch repair (dMMR) results in microsatellite instability (MSI), a pronounced
mutator phenotype. High‐frequency MSI (MSI‐H)/dMMR is gaining increasing interest as a …

Gastrointestinal (GI) cancers include hepatobiliary tumors, pancreatic cancer (PC),
neuroendocrine tumors of the gastrointestinal tract, small bowel carcinomas, gastric cancer …

Despite the existence of effective therapy options for patients with localized colorectal
cancer, advanced-stage patients have limited therapies. Genomic profiling is a promising …

Objective Screening the immune-related genes of colorectal cancer based on clinical next
generation sequencing and construction of an immune-related prognostic risk model, so as …

Аннотация В статье представлены изменения клинических рекомендаций по лечению
метастатического рака толстой кишки в 2024 г. Новые положения в клинических …