We now know that cancer is many different diseases, with great variation even within a
single histological subtype. With the current emphasis on developing personalized …

Nearly all human complex traits and disease phenotypes exhibit some degree of sex
differences, including differences in prevalence, age of onset, severity or disease …

We determined the relationships between DNA sequence variation and DNA methylation
using blood samples from 3,799 Europeans and 3,195 South Asians. We identify …

Despite their known importance in clinical medicine, differences based on sex and gender
are among the least studied factors affecting cancer susceptibility, progression, survival, and …

In epigenome-wide association studies (EWAS), different methylation profiles of distinct cell
types may lead to false discoveries. We introduce ReFACTor, a method based on principal …

In primary Sjögren syndrome (pSS), chronic inflammation of exocrine glands results in tissue
destruction and sicca symptoms, primarily of the mouth and eyes. Fatigue, arthralgia and …

Individuals with germ line variants associated with hereditary hematopoietic malignancies
(HHMs) have a highly variable risk for leukemogenesis. Gaps in our understanding of …

Background Sex differences are known to play a role in disease aetiology, progression and
outcome. Previous studies have revealed autosomal epigenetic differences between males …

Phenotypic sex-based differences exist for many complex traits. In other cases, phenotypes
may be similar, but underlying biology may vary. Thus, sex-aware genetic analyses are …

High costs and technical limitations of cell sorting and single-cell techniques currently
restrict the collection of large-scale, cell-type-specific DNA methylation data. This, in turn …