The oral cavity and oropharynx are complex environments that are susceptible to physical,
chemical, and microbiological insults. They are also common sites for pathological and …

The tooth provides an excellent system for deciphering the molecular mechanisms of
organogenesis, and has thus been of longstanding interest to developmental and stem cell …

Reciprocal interactions between epithelial and mesenchymal tissues play a fundamental
role in the morphogenesis of teeth and regulate all aspects of tooth development. Extensive …

Teeth are found in almost all vertebrates, and they therefore provide a general paradigm for
the study of epithelial organ development and evolution. Here, we review the developmental …

Tooth enamel is a complex mineralized tissue consisting of long and parallel apatite crystals
configured into decussating enamel rods. In recent years, multiple approaches have been …

Dental anomalies are caused by complex interactions between genetic, epigenetic and
environmental factors during the long process of dental development. This process is …

Teeth develop as ectodermal appendages from epithelial and mesenchymal tissues. Tooth
organogenesis is regulated by an intricate network of cell–cell signaling during all steps of …

Signaling pathways invoke interplays between forward signaling and feedback to drive
robust cellular response. In this study, we address the dynamics of growth factor signaling …

One motivation in the study of development is the discovery of mechanisms that may guide
evolutionary change. Here we report how development governs relative size and number of …

Diverse cellular processes are regulated by tyrosyl phosphorylation, which is controlled by
protein-tyrosine kinases (PTKs) and protein-tyrosine phosphatases (PTPs). De-regulated …