Diagnosis and management of pituitary adenomas: a review

NA Tritos, KK Miller - Jama, 2023 - jamanetwork.com
Importance Pituitary adenomas are neoplasms of the pituitary adenohypophyseal cell
lineage and include functioning tumors, characterized by the secretion of pituitary hormones …

Cushing syndrome: a review

M Reincke, M Fleseriu - Jama, 2023 - jamanetwork.com
Importance Cushing syndrome is defined as a prolonged increase in plasma cortisol levels
that is not due to a physiological etiology. Although the most frequent cause of Cushing …

Cushing's syndrome

M Gadelha, F Gatto, LE Wildemberg, M Fleseriu - The Lancet, 2023 - thelancet.com
Endogenous Cushing's syndrome results from excess glucocorticoid secretion, which leads
to a myriad of clinical manifestations, comorbidities, and increased mortality despite …

An individualized approach to the management of Cushing disease

M Fleseriu, EV Varlamov, JM Hinojosa-Amaya… - Nature Reviews …, 2023 - nature.com
Cushing disease caused by an adrenocorticotropic hormone (ACTH)-secreting pituitary
corticotroph adenoma leads to hypercortisolaemia with high mortality due to metabolic …

Pathogenic role of acyl coenzyme A binding protein (ACBP) in Cushing's syndrome

H Pan, AL Tian, H Chen, Y Xia, A Sauvat… - Nature …, 2024 - nature.com
Cushing's syndrome is caused by an elevation of endogenous or pharmacologically
administered glucocorticoids. Acyl coenzyme A binding protein (ACBP, encoded by the …

Second-line tests in the differential diagnosis of neoplastic and non-neoplastic hypercortisolism: a systematic review and meta-analysis

A Mondin, M Barbot, G Voltan, I Tizianel… - Journal of …, 2023 - Springer
Purpose The clinical and hormonal overlap between neoplastic (CS) and non-neoplastic
(NNH/pCS) hypercortisolism is a challenge. Various dynamic tests have been proposed to …

Low-grade inflammation during the glucocorticoid withdrawal phase in patients with Cushing's syndrome

F Vogel, L Braun, S Zopp, E Nowak… - European Journal of …, 2023 - academic.oup.com
Abstract Importance Endogenous Cushing's syndrome (CS) leads to profound
immunosuppression. Successful surgery induces biochemical remission and reversal of …

Development of human pituitary neuroendocrine tumor organoids to facilitate effective targeted treatments of Cushing's disease

J Chakrabarti, R Pandey, JM Churko, J Eschbacher… - Cells, 2022 - mdpi.com
(1) Background: Cushing's disease (CD) is a serious endocrine disorder caused by an
adrenocorticotropic hormone (ACTH)-secreting pituitary neuroendocrine tumor (PitNET) that …

A proposed clinical classification for pituitary neoplasms to guide therapy and prognosis

KKY Ho, M Fleseriu, J Wass, L Katznelson… - The Lancet Diabetes & …, 2024 - thelancet.com
No comprehensive classification system that guides prognosis and therapy of pituitary
adenomas exists. The 2022 WHO histopathology-based classification system can only be …

Pachychoroid spectrum diseases in patients with Cushing's syndrome: a systematic review with meta-analyses

JK Holtz, JME Larsson, MS Hansen… - Journal of Clinical …, 2022 - mdpi.com
Cushing's syndrome is a rare disease with an endogenous cause of excess cortisol
secretion. More evidence substantially links cortisol levels to the pachychoroid spectrum …