[HTML][HTML] Unveiling the angiogenic effects of cannabinoids: enhancers or inhibitors?

J Maia, BM Fonseca, N Teixeira… - Biochemical …, 2023 - Elsevier
Cannabinoids are compounds found in the cannabis sativa plant. Cannabinoids, such as
delta-9-tetrahydrocannabinol (THC) and cannabidiol (CBD), have potential therapeutic …

The expression analyses of GSK3B, VEGF, ANG1, and ANG2 in human brain microvascular endothelial cells treated with the synthetic cannabinoid XLR-11

ALE Laith, S Alahmad - Gene, 2023 - Elsevier
The endocannabinoid system receptors, cannabinoid receptors type-1 (CBR-1) and− 2
(CBR-2), are implicated in several behavioral and cognitive processes. Many studies have …

URB597 and Andrographolide Improve Brain Microvascular Endothelial Cell Permeability and Apoptosis by Reducing Oxidative Stress and Inflammation Associated …

DP Wang, K Kang, J Sun, Q Lin… - Oxidative Medicine and …, 2022 - Wiley Online Library
Ischemic stroke, a cerebrovascular disease worldwide, triggers a cascade of
pathophysiological events, including blood‐brain barrier (BBB) breakdown. Brain …

The synthetic cannabinoid 5F-MDMB-PICA enhances the metabolic activity and angiogenesis in human brain microvascular endothelial cells by upregulation of VEGF …

LN Al-Eitan, SZ Alahmad, MFM ElMotasem… - Toxicology …, 2023 - academic.oup.com
Brain angiogenesis, the formation of new blood vessels from existing brain vasculature, has
been previously associated with neural plasticity and addictive behaviors related to …

Novel psychoactive substances: the razor's edge between therapeutical potential and psychoactive recreational misuse

B Correia, J Fernandes, MJ Botica, C Ferreira… - Medicines, 2022 - mdpi.com
Background: Novel psychoactive substances (NPS) are compounds of natural and synthetic
origin, similar to traditional drugs of abuse. NPS are involved in a contemporary trend whose …

Donepezil ameliorates oxygen-glucose deprivation/reoxygenation-induced brain microvascular endothelial cell dysfunction via the SIRT1/FOXO3a/NF-κB pathways

X Sun, B Liu - Bioengineered, 2022 - Taylor & Francis
Ischemic stroke is a disease in which brain tissue is damaged by a sudden rupture or
blockage of a blood vessel in the brain that prevents blood from flowing to the brain …

The effects of cannabinoids on the kidney

S Didik, O Palygin, M Chandy… - Acta …, 2024 - Wiley Online Library
Cannabinoids are a class of drugs derived from the Cannabis plant that are widely used for
the treatment of various medical conditions and recreational use. Common examples …

The effect of the synthetic cannabinoid AB-CHMINACA on the roles of vascular endothelial growth factor, angiopoietin-1, and angiopoietin-2 in brain angiogenesis

L AL-Eitan, H Abu Kharmah - Applied In Vitro Toxicology, 2023 - liebertpub.com
Introduction: Synthetic cannabinoids (SCs) are new psychoactive compound that mimic the
actions of tetrahydrocannabinol, the main psychoactive ingredient in cannabis …

MDMB-FUBINACA influences brain angiogenesis and the expression of VEGF, ANG-1, and ANG-2

L Al-Eitan, M Alkhawaldeh - Current Vascular Pharmacology, 2023 - ingentaconnect.com
Aim: This study aims to explore the impact of the synthetic cannabinoid methyl 2-(1-(4-
fluorobenzyl)-1H-indazole-3-carboxamido)-3, 3-dimethylbutanoate (MDMB-FUBINACA) on …

Effect of EMB-FUBINACA on brain endothelial cell angiogenesis: expression analysis of angiogenic markers

L Al-Eitan, HA Kharmah - Naunyn-Schmiedeberg's Archives of …, 2024 - Springer
Angiogenesis is the process by which blood vessels are generated from preexisting ones.
Synthetic cannabinoids represent new psychoactive substances that bind to the …