Sensitivity of transcription factors to DNA methylation
Dynamic binding of transcription factors (TFs) to regulatory elements controls transcriptional
states throughout organism development. Epigenetics modifications, such as DNA …
states throughout organism development. Epigenetics modifications, such as DNA …
Epigenetic modulators, modifiers and mediators in cancer aetiology and progression
This year is the tenth anniversary of the publication in this journal of a model suggesting the
existence of'tumour progenitor genes'. These genes are epigenetically disrupted at the …
existence of'tumour progenitor genes'. These genes are epigenetically disrupted at the …
Elimination of oncogenic KRAS in genetic mouse models eradicates pancreatic cancer by inducing FAS-dependent apoptosis by CD8+ T cells
Summary Oncogenic KRAS G12D (KRAS∗) is critical for the initiation and maintenance of
pancreatic ductal adenocarcinoma (PDAC) and is a known repressor of tumor immunity …
pancreatic ductal adenocarcinoma (PDAC) and is a known repressor of tumor immunity …
BET bromodomain inhibition suppresses the function of hematopoietic transcription factors in acute myeloid leukemia
The bromodomain and extraterminal (BET) protein BRD4 is a validated drug target in
leukemia, yet its regulatory function in this disease is not well understood. Here, we show …
leukemia, yet its regulatory function in this disease is not well understood. Here, we show …
The human methyltransferase ZCCHC4 catalyses N6-methyladenosine modification of 28S ribosomal RNA
RNA methylations are essential both for RNA structure and function, and are introduced by a
number of distinct methyltransferases (MTases). In recent years, N 6-methyladenosine …
number of distinct methyltransferases (MTases). In recent years, N 6-methyladenosine …
The BRAF oncoprotein functions through the transcriptional repressor MAFG to mediate the CpG Island Methylator phenotype
Most colorectal cancers (CRCs) containing activated BRAF (BRAF [V600E]) have a CpG
island methylator phenotype (CIMP) characterized by aberrant hypermethylation of many …
island methylator phenotype (CIMP) characterized by aberrant hypermethylation of many …
Inhibition of Enhancer of zeste homolog 2 (EZH2) induces natural killer cell-mediated eradication of hepatocellular carcinoma cells
S Bugide, MR Green… - Proceedings of the …, 2018 - National Acad Sciences
Natural killer (NK) cell-mediated tumor cell eradication could inhibit tumor initiation and
progression. However, the factors that regulate NK cell-mediated cancer cell eradication …
progression. However, the factors that regulate NK cell-mediated cancer cell eradication …
The acinar differentiation determinant PTF1A inhibits initiation of pancreatic ductal adenocarcinoma
Understanding the initiation and progression of pancreatic ductal adenocarcinoma (PDAC)
may provide therapeutic strategies for this deadly disease. Recently, we and others made …
may provide therapeutic strategies for this deadly disease. Recently, we and others made …
[HTML][HTML] FOSL1 promotes metastasis of head and neck squamous cell carcinoma through super-enhancer-driven transcription program
Previously, we discovered that FOSL1 facilitates the metastasis of head and neck squamous
cell carcinoma (HNSCC) cancer stem cells in a spontaneous mouse model. However, the …
cell carcinoma (HNSCC) cancer stem cells in a spontaneous mouse model. However, the …
PLK1 and HOTAIR Accelerate Proteasomal Degradation of SUZ12 and ZNF198 during Hepatitis B Virus–Induced Liver Carcinogenesis
Elucidating mechanisms of hepatitis B virus (HBV)–mediated hepatocarcinogenesis is
needed to gain insights into the etiology and treatment of liver cancer. Cells where HBV is …
needed to gain insights into the etiology and treatment of liver cancer. Cells where HBV is …