Bridging tissue repair and epithelial carcinogenesis: epigenetic memory and field cancerization

C Levra Levron, L Elettrico, C Duval… - Cell Death & …, 2024 - nature.com
The epigenome coordinates spatial-temporal specific gene expression during development
and in adulthood, for the maintenance of homeostasis and upon tissue repair. The upheaval …

Neuronal enhancers fine-tune adaptive circuit plasticity

EC Griffith, AE West, ME Greenberg - Neuron, 2024 - cell.com
Neuronal activity-regulated gene expression plays a crucial role in sculpting neural circuits
that underpin adaptive brain function. Transcriptional enhancers are now recognized as key …

Prior Fc receptor activation primes macrophages for increased sensitivity to IgG via long-term and short-term mechanisms

A Bond, S Fiaz, K Rollins, JEQ Nario, ET Snyder… - Developmental Cell, 2024 - cell.com
Macrophages measure the" eat-me" signal immunoglobulin G (IgG) to identify targets for
phagocytosis. We tested whether prior encounters with IgG influence macrophage appetite …

To live or let die? Epigenetic adaptations to climate change—a review

J Zetzsche, M Fallet - Environmental epigenetics, 2024 - academic.oup.com
Anthropogenic activities are responsible for a wide array of environmental disturbances that
threaten biodiversity. Climate change, encompassing temperature increases, ocean …

Force-induced Caspase-1-dependent pyroptosis regulates orthodontic tooth movement

L Chen, H Yu, Z Li, Y Wang, S Jin, M Yu… - International Journal of …, 2024 - nature.com
Pyroptosis, an inflammatory caspase-dependent programmed cell death, plays a vital role in
maintaining tissue homeostasis and activating inflammatory responses. Orthodontic tooth …

[HTML][HTML] Transcriptional and Metabolic Changes Following Repeated Fasting and Refeeding of Adipose Stem Cells Highlight Adipose Tissue Resilience

NM Galigniana, M Abdelhalim, P Collas, T Sæther - Nutrients, 2024 - mdpi.com
Background: Obesity and related metabolic disorders have reached epidemic levels, calling
for diverse therapeutic strategies. Altering nutrient intake, timing and quantity by intermittent …

[HTML][HTML] Development of adaptive anoikis resistance promotes metastasis that can be overcome by CDK8/19 Mediator kinase inhibition

M Monavarian, EF Page, R Rajkarnikar, A Kumari… - bioRxiv, 2023 - ncbi.nlm.nih.gov
Anoikis resistance or evasion of cell death triggered by cell detachment into suspension is a
hallmark of cancer that is concurrent with cell survival and metastasis. The effects of frequent …

Epigenetic Inheritance

M Fallet - Epigenetics in Biological Communication, 2024 - Springer
The field of epigenetics, orchestrating molecular communication at the genome-phenotype
interface, has gained significant importance over the last decades. Mitotic inheritance …

Transcriptional memory is conferred by combined heritable maintenance and local removal of selective chromatin modifications

P Mikulski, SSH Tehrani, A Kogan, I Abdul-Zani… - bioRxiv, 2023 - biorxiv.org
Interferon-γ (IFNγ) transiently activates genes involved in inflammation and innate immunity.
A subset of targets maintain a mitotically heritable memory of prior IFNγ exposure resulting …