Late-stage functionalization (LSF) constitutes a powerful strategy for the assembly or
diversification of novel molecular entities with improved physicochemical or biological …

Copper-catalyzed enantioselective coupling has been widely investigated, which allows
rapid construction of various chiral molecules. Despite important advances via polar and …

The conversion of CO2 to valuable chemicals is highly desirable for sustainable
development. Among the various methods available, the difunctionalizing carboxylation of …

The arylethylamine pharmacophore is conserved across a range of biologically active
natural products and pharmaceuticals, particularly in molecules that act on the central …

Asymmetric sp3 C–H functionalization has been demonstrated to substantially expedite
target molecule synthesis, spanning from feedstocks upgradation to late-stage modification …

The first enantioselective radical trifluoromethylation of benzylic C–H bonds has been
established by a cooperative photoredox and copper catalysis system, providing …

Radical C–H functionalization represents a useful means of streamlining synthetic routes by
avoiding substrate preactivation and allowing access to target molecules in fewer steps. The …

Conspectus Peptides are essential components of living systems and contribute to critical
biological processes, such as cell proliferation, immune defense, tumor formation, and …

Copper-catalyzed radical-relay reactions provide a versatile strategy for selective C–H
functionalization; however, reactions with peroxide-based oxidants often require excess C …

Site-selective radical reactions of benzylic C–H bonds are now highly effective methods for
C (sp3–H) functionalization and cross-coupling. The existing methods, however, are often …