R loops: new modulators of genome dynamics and function
JM Santos-Pereira, A Aguilera - Nature Reviews Genetics, 2015 - nature.com
R loops are nucleic acid structures composed of an RNA–DNA hybrid and a displaced
single-stranded DNA. Recently, evidence has emerged that R loops occur more often in the …
single-stranded DNA. Recently, evidence has emerged that R loops occur more often in the …
Computational approaches for functional prediction and characterisation of long noncoding RNAs
Although a considerable portion of eukaryotic genomes is transcribed as long noncoding
RNAs (lncRNAs), the vast majority are functionally uncharacterised. The rapidly expanding …
RNAs (lncRNAs), the vast majority are functionally uncharacterised. The rapidly expanding …
The molecular landscape of ETMR at diagnosis and relapse
Embryonal tumours with multilayered rosettes (ETMRs) are aggressive paediatric embryonal
brain tumours with a universally poor prognosis. Here we collected 193 primary ETMRs and …
brain tumours with a universally poor prognosis. Here we collected 193 primary ETMRs and …
[HTML][HTML] HOTTIP-dependent R-loop formation regulates CTCF boundary activity and TAD integrity in leukemia
HOTTIP lncRNA is highly expressed in acute myeloid leukemia (AML) driven by MLL
rearrangements or NPM1 mutations to mediate HOXA topologically associated domain …
rearrangements or NPM1 mutations to mediate HOXA topologically associated domain …
MYCN amplification and ATRX mutations are incompatible in neuroblastoma
Aggressive cancers often have activating mutations in growth-controlling oncogenes and
inactivating mutations in tumor-suppressor genes. In neuroblastoma, amplification of the …
inactivating mutations in tumor-suppressor genes. In neuroblastoma, amplification of the …
RNA-DNA hybrid (R-loop) immunoprecipitation mapping: an analytical workflow to evaluate inherent biases
The impact of R-loops on the physiology and pathology of chromosomes has been
demonstrated extensively by chromatin biology research. The progress in this field has been …
demonstrated extensively by chromatin biology research. The progress in this field has been …
Regulation and function of R-loops at repetitive elements
A Gambelli, A Ferrando, C Boncristiani, S Schoeftner - Biochimie, 2023 - Elsevier
R-loops are atypical, three-stranded nucleic acid structures that contain a stretch of RNA:
DNA hybrids and an unpaired, single stranded DNA loop. R-loops are physiological relevant …
DNA hybrids and an unpaired, single stranded DNA loop. R-loops are physiological relevant …
Bacterial homologs of innate eukaryotic antiviral defenses with anti-phage activity highlight shared evolutionary roots of viral defenses
DF van den Berg, AR Costa, JQ Esser, I Stanciu… - Cell Host & Microbe, 2024 - cell.com
Prokaryotes have evolved a multitude of defense systems to protect against phage
predation. Some of these resemble eukaryotic genes involved in antiviral responses. Here …
predation. Some of these resemble eukaryotic genes involved in antiviral responses. Here …
R‐loop: The new genome regulatory element in plants
J Zhou, W Zhang, Q Sun - Journal of integrative plant biology, 2022 - Wiley Online Library
An R‐loop is a three‐stranded chromatin structure that consists of a displaced single strand
of DNA and an RNA: DNA hybrid duplex, which was thought to be a rare by‐product of …
of DNA and an RNA: DNA hybrid duplex, which was thought to be a rare by‐product of …
The SUMOylated METTL8 induces R-loop and tumorigenesis via m3C
LH Zhang, XY Zhang, T Hu, XY Chen, JJ Li, M Raida… - Iscience, 2020 - cell.com
R-loops, three-stranded DNA-DNA: RNA hybrid structures, are best known for their
deleterious effects on genome stability. The regulatory factors of this fundamental genetic …
deleterious effects on genome stability. The regulatory factors of this fundamental genetic …