The cytokine Fms-like tyrosine kinase 3 ligand (FL) is an important regulator of
hematopoiesis. Its receptor, Flt3, is expressed on myeloid, lymphoid and dendritic cell …

Receptor tyrosine kinases couple a wide variety of extracellular cues to cellular responses.
The class III subfamily comprises the platelet-derived growth factor receptor, c-Kit, Flt3 and c …

The fms-related tyrosine kinase 3 (FLT3) receptor has been extensively studied over the
past two decades with regard to oncogenic alterations that do not only serve as prognostic …

Allogeneic hematopoietic cell transplantation (alloHCT) as a postremission therapy in
patients with FLT3-ITD–positive intermediate-risk acute myeloid leukemia (AML) remains …

Purpose: CBL is a negative regulator of activated receptor tyrosine kinases (RTK). In this
study, we determined the frequency of CBL mutations in acute leukemias and evaluated the …

The mechanism of cell transformation by Fms-like tyrosine kinase 3 (FLT3) in acute myeloid
leukemia (AML) is incompletely understood. The most prevalent activated mutant FLT3 ITD …

The class III receptor tyrosine kinase FMS-like tyrosine kinase 3 (FLT3) regulates normal
hematopoiesis and immunological functions. Nonetheless, constitutively active mutant FLT3 …

This review describes the effects of FLT3 mutations that alter its intracellular localization and
modify its glycosylation, leading to differences in downstream signaling pathways. The most …

OBJECTIVE: Internal tandem duplication (ITD) mutations of the FLT3 receptor are
associated with a high incidence of relapse in acute myeloid leukemia (AML). Expression of …

Kit is a cell surface type III tyrosine kinase (TK) receptor implicated in cell transformation
through overexpression or oncogenic mutation. Two categories of Kit mutants displaying …