[HTML][HTML] Sexual dimorphism and gender in infectious diseases

L Gay, C Melenotte, I Lakbar, S Mezouar… - Frontiers in …, 2021 - frontiersin.org
Epidemiological studies and clinical observations show evidence of sexual dimorphism in
infectious diseases. Women are at less risk than men when it comes to developing most …

Sex influences immune responses to viruses, and efficacy of prophylaxis and treatments for viral diseases

SL Klein - Bioessays, 2012 - Wiley Online Library
The intensity and prevalence of viral infections are typically higher in males, whereas
disease outcome can be worse for females. Females mount higher innate and adaptive …

Sex disparities and neutralizing-antibody durability to SARS-CoV-2 infection in convalescent individuals

AJ Markmann, N Giallourou, DR Bhowmik, YJ Hou… - Msphere, 2021 - Am Soc Microbiol
ABSTRACT The coronavirus disease 2019 (COVID-19) pandemic, caused by severe acute
respiratory syndrome-related coronavirus 2 (SARS-CoV-2) has now caused over 2 million …

[HTML][HTML] Cytokines and STATs in liver fibrosis

X Kong, N Horiguchi, M Mori, B Gao - Frontiers in physiology, 2012 - frontiersin.org
Liver fibrosis, or cirrhosis, is a common end-stage condition of many chronic liver diseases
after incomplete recovery from hepatocyte damage. During fibrosis progression …

[HTML][HTML] Extracellular hepatitis C virus core protein activates STAT3 in human monocytes/macrophages/dendritic cells via an IL-6 autocrine pathway

RS Tacke, A Tosello-Trampont, V Nguyen… - Journal of Biological …, 2011 - ASBMB
Hepatitis C virus (HCV) infection is highly efficient in the establishment of persistent
infection, which leads to the development of chronic liver disease and hepatocellular …

Genetic polymorphisms of IL6 gene–174G> C and–597G> A are associated with the risk of COVID‐19 severity

S Verma, S Verma, FH Khan, Z Siddiqi… - International Journal …, 2023 - Wiley Online Library
Abstract Coronavirus disease‐2019 (COVID‐19) is pro‐inflammatory disorder characterized
by acute respiratory distress syndrome. Interleukin‐6, a cytokine secreted by macrophages …

A functional single-nucleotide polymorphism in the promoter of the gene encoding interleukin 6 is associated with susceptibility to tuberculosis

G Zhang, B Zhou, W Wang, M Zhang… - The Journal of …, 2012 - academic.oup.com
Background Genetic variation influences susceptibility or resistance to tuberculosis.
Interleukin 6 (IL-6) contributes to protection against tuberculosis in mice. However, its role in …

[HTML][HTML] Role of cytokines and other factors involved in the Mycobacterium tuberculosis infection

TB Romero-Adrian, J Leal-Montiel… - World Journal of …, 2015 - wjgnet.com
Mycobacterium tuberculosis (Mtb) is a pathogen that is widely distributed geographically
and continues to be a major threat to world health. Bacterial virulence factors, nutritional …

A low-producing haplotype of interleukin-6 disrupting CTCF binding is protective against severe COVID-19

T Chen, YX Lin, Y Zha, Y Sun, J Tian, Z Yang, SW Lin… - MBio, 2021 - Am Soc Microbiol
ABSTRACT Interleukin6 (IL-6) is a key driver of hyperinflammation in COVID-19, and its
level strongly correlates with disease progression. To investigate whether variability in …

Genetic and immunological evidence implicates interleukin 6 as a susceptibility gene for leprosy type 2 reaction

ALM Sousa, VM Fava, LH Sampaio… - Journal of Infectious …, 2012 - academic.oup.com
In leprosy, type 1 reaction (T1R) and type 2 reaction (T2R) are major causes of nerve injury
and permanent disabilities. A previous study on plasma levels of 27 cytokines in patients …