Advances in microfluidics: technical innovations and applications in diagnostics and therapeutics

G Aubry, HJ Lee, H Lu - Analytical Chemistry, 2023 - ACS Publications
Microfluidics describes the study of systems that operate fluids at miniature scales, often in
microchannels. It is powerful in scaling down biological experiments by many orders of …

Advanced materials and sensors for microphysiological systems: focus on electronic and electrooptical interfaces

H Kavand, R Nasiri, A Herland - Advanced Materials, 2022 - Wiley Online Library
Advanced in vitro cell culture systems or microphysiological systems (MPSs), including
microfluidic organ‐on‐a‐chip (OoC), are breakthrough technologies in biomedicine. These …

Nanostructured surface plasmon resonance sensors: Toward narrow linewidths

K Yang, Y Chen, S Yan, W Yang - Heliyon, 2023 - cell.com
Surface plasmon resonance sensors have found wide applications in optical sensing field
due to their excellent sensitivity to the slight refractive index change of surrounding medium …

Liver‐on‐a‐Chip Integrated with Label‐Free Optical Biosensors for Rapid and Continuous Monitoring of Drug‐Induced Toxicity

JW Yang, D Khorsandi, L Trabucco, M Ahmed… - Small, 2024 - Wiley Online Library
Drug toxicity assays using conventional 2D static cultures and animal studies have
limitations preventing the translation of potential drugs to the clinic. The recent development …

Microfluidic platforms for single cell analysis: applications in cellular manipulation and optical biosensing

S Kumari, U Saha, M Bose, D Murugan, V Pachauri… - Chemosensors, 2023 - mdpi.com
Cellular heterogeneity of any tissue or organ makes it challenging to identify and study the
impact and the treatment of any disease. In this context, analysis of cells at an individual …

Polymer-based chemical-nose systems for optical-pattern recognition of gut microbiota

S Tomita, H Kusada, N Kojima, S Ishihara… - Chemical …, 2022 - pubs.rsc.org
Gut-microbiota analysis has been recognized as crucial in health management and disease
treatment. Metagenomics, a current standard examination method for the gut microbiome, is …

A polymer-based chemical tongue for the non-invasive monitoring of osteogenic stem-cell differentiation by pattern recognition of serum-supplemented spent media

S Tomita, S Ishihara, R Kurita - Journal of Materials Chemistry B, 2022 - pubs.rsc.org
The development of non-invasive techniques to characterize cultured cells is invaluable not
only to ensure the reproducibility of cell research, but also for quality assurance of industrial …

Synergizing microfluidics and plasmonics: advances, applications, and future directions

C Escobedo, AG Brolo - Lab on a Chip, 2025 - pubs.rsc.org
In the past decade, interest in nanoplasmonic structures has experienced significant growth,
owing to rapid advancements in materials science and the evolution of novel …

Cell-based chemical safety assessment and therapeutic discovery using array-based sensors

M Jiang, AN Chattopadhyay, VM Rotello - International Journal of …, 2022 - mdpi.com
Synthetic chemicals are widely used in food, agriculture, and medicine, making chemical
safety assessments necessary for environmental exposure. In addition, the rapid …

Damage-free evaluation of cultured cells based on multivariate analysis with a single-polymer probe

H Sugai, S Tomita, S Ishihara, K Shiraki… - Chemical …, 2022 - pubs.rsc.org
We present a pattern-recognition-based sensor that targets cell-derived components in
culture media and evaluates cultured cells without damaging them. An array sensor made of …