Fine-tuning cellular physiology in response to intracellular and environmental cues requires
precise temporal and spatial control of gene expression. High-resolution imaging …

The spatial regulation of protein translation is an efficient way to create functional and
structural asymmetries in cells. Recent research has furthered our understanding of how …

RNAs in cells are associated with RNA-binding proteins (RBPs) to form ribonucleoprotein
(RNP) complexes. The RBPs influence the structure and interactions of the RNAs and play …

To facilitate studies of the yeast proteome, we cloned 5800 open reading frames and
overexpressed and purified their corresponding proteins. The proteins were printed onto …

The myosin family of actin filament-based molecular motors consists of at least 20
structurally and functionally distinct classes. The human genome contains nearly 40 myosin …

Abstract mRNA localization is a common mechanism for targeting proteins to regions of the
cell where they are required. It has an essential role in localizing cytoplasmic determinants …

Cytoplasmic messenger RNA localization is a key post-transcriptional mechanism of
establishing spatially restricted protein synthesis. The characterization of cis-acting signals …

▪ Abstract Cell polarity, as reflected by polarized growth and organelle segregation during
cell division in yeast, appears to follow a simple hierarchy. On the basis of physical cues …

The formation of protein complexes is crucial to most biological functions. The cellular
mechanisms governing protein complex biogenesis are not yet well understood, but some …

The cell has many ways to regulate the production of proteins. One mechanism is through
the changes to the machinery of translation initiation. These alterations favor the translation …