[HTML][HTML] Coronavirus biology and replication: implications for SARS-CoV-2

P V'kovski, A Kratzel, S Steiner, H Stalder… - Nature Reviews …, 2021 - nature.com
The SARS-CoV-2 pandemic and its unprecedented global societal and economic disruptive
impact has marked the third zoonotic introduction of a highly pathogenic coronavirus into the …

The natural history, pathobiology, and clinical manifestations of SARS-CoV-2 infections

J Machhi, J Herskovitz, AM Senan, D Dutta… - Journal of neuroimmune …, 2020 - Springer
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the etiological agent of
coronavirus disease 2019 (COVID-19). SARS-CoV-2, is a positive-sense single-stranded …

SARS-CoV-2-specific T cell immunity in cases of COVID-19 and SARS, and uninfected controls

N Le Bert, AT Tan, K Kunasegaran, CYL Tham… - Nature, 2020 - nature.com
Memory T cells induced by previous pathogens can shape susceptibility to, and the clinical
severity of, subsequent infections. Little is known about the presence in humans of pre …

[HTML][HTML] Targets of T cell responses to SARS-CoV-2 coronavirus in humans with COVID-19 disease and unexposed individuals

A Grifoni, D Weiskopf, SI Ramirez, J Mateus, JM Dan… - Cell, 2020 - cell.com
Understanding adaptive immunity to SARS-CoV-2 is important for vaccine development,
interpreting coronavirus disease 2019 (COVID-19) pathogenesis, and calibration of …

The architecture of SARS-CoV-2 transcriptome

D Kim, JY Lee, JS Yang, JW Kim, VN Kim, H Chang - Cell, 2020 - cell.com
SARS-CoV-2 is a betacoronavirus responsible for the COVID-19 pandemic. Although the
SARS-CoV-2 genome was reported recently, its transcriptomic architecture is unknown …

[HTML][HTML] The coding capacity of SARS-CoV-2

Y Finkel, O Mizrahi, A Nachshon… - Nature, 2021 - nature.com
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the cause of the ongoing
coronavirus disease 2019 (COVID-19) pandemic 1. To understand the pathogenicity and …

The molecular virology of coronaviruses

E Hartenian, D Nandakumar, A Lari, M Ly… - Journal of Biological …, 2020 - ASBMB
Few human pathogens have been the focus of as much concentrated worldwide attention as
severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the cause of COVID-19. Its …

Characterisation of the transcriptome and proteome of SARS-CoV-2 reveals a cell passage induced in-frame deletion of the furin-like cleavage site from the spike …

AD Davidson, MK Williamson, S Lewis, D Shoemark… - Genome medicine, 2020 - Springer
Background SARS-CoV-2 is a recently emerged respiratory pathogen that has significantly
impacted global human health. We wanted to rapidly characterise the transcriptomic …

SARS-CoV-2 uses a multipronged strategy to impede host protein synthesis

Y Finkel, A Gluck, A Nachshon, R Winkler, T Fisher… - Nature, 2021 - nature.com
The coronavirus SARS-CoV-2 is the cause of the ongoing pandemic of COVID-19.
Coronaviruses have developed a variety of mechanisms to repress host mRNA translation to …

Human coronavirus: host-pathogen interaction

TS Fung, DX Liu - Annual review of microbiology, 2019 - annualreviews.org
Human coronavirus (HCoV) infection causes respiratory diseases with mild to severe
outcomes. In the last 15 years, we have witnessed the emergence of two zoonotic, highly …