Lymphocyte sparing normal tissue effects in the clinic (LymphoTEC): a systematic review of dose constraint considerations to mitigate radiation-related lymphopenia in …
Background Radiation-related lymphopenia has been associated with suboptimal tumor
control rates leading to inferior survival outcomes. To date, no standardized dose constraints …
control rates leading to inferior survival outcomes. To date, no standardized dose constraints …
Radio-induced lymphopenia in the era of anti-cancer immunotherapy
Radiation-induced lymphopenia (RIL) is characterized by a significant decrease in the
absolute number of lymphocytes circulating in the blood after radiotherapy. With the major …
absolute number of lymphocytes circulating in the blood after radiotherapy. With the major …
[HTML][HTML] Severe radiation-induced lymphopenia attenuates the benefit of durvalumab after concurrent chemoradiotherapy for NSCLC
W Jing, T Xu, L Wu, PB Lopez, C Grassberger… - JTO Clinical and …, 2022 - Elsevier
Introduction Durvalumab after concurrent chemoradiation (CCRT) for NSCLC improves
survival, but only in a subset of patients. We investigated the effect of severe radiation …
survival, but only in a subset of patients. We investigated the effect of severe radiation …
Severe lymphopenia during chemoradiation therapy for esophageal cancer: Comprehensive analysis of randomized phase 2B trial of proton beam therapy versus …
Purpose Lymphocytes play an important role in antitumor immunity; however, they are also
especially vulnerable to depletion during chemoradiation therapy (CRT). The purpose of this …
especially vulnerable to depletion during chemoradiation therapy (CRT). The purpose of this …
Severe radiation-induced lymphopenia affects the outcomes of esophageal cancer: a comprehensive systematic review and meta-analysis
D Dai, Q Tian, G Yu, Y Shui, H Jiang, Q Wei - Cancers, 2022 - mdpi.com
Simple Summary Radiotherapy is as an important part of esophageal cancer (EC) treatment.
However, it often causes severe radiation-induced lymphopenia (RIL). The aim of the current …
However, it often causes severe radiation-induced lymphopenia (RIL). The aim of the current …
Prognostic impact of radiotherapy-induced-lymphopenia in patients treated with breast-conservative surgery
CI Yoon, J Hwang, D Kim, JH Ji, J Lee, SJ Bae… - Scientific reports, 2023 - nature.com
We investigated a prognostic impact of radiotherapy-induced lymphopenia (RIL) in breast
cancer patients treated with breast-conservative surgery (BCS). We included 531 breast …
cancer patients treated with breast-conservative surgery (BCS). We included 531 breast …
The impact of radiation induced lymphopenia in the prognosis of head and neck cancer: A systematic review and meta-analysis
D Dai, Q Tian, Y Shui, J Li, Q Wei - Radiotherapy and Oncology, 2022 - Elsevier
Objectives Radiotherapy is a key part of head and neck cancer (HNC) treatment. Radiation
induced lymphopenia (RIL) is a severe complication of radiotherapy. The aim of this study …
induced lymphopenia (RIL) is a severe complication of radiotherapy. The aim of this study …
On the interplay between dosiomics and genomics in radiation-induced lymphopenia of lung cancer patients
Purpose To investigate the interplay between spatial dose patterns and single nucleotide
polymorphisms in the development of radiation-induced lymphopenia (RIL) in 186 non-small …
polymorphisms in the development of radiation-induced lymphopenia (RIL) in 186 non-small …
The need for paradigm shift: prognostic significance and implications of standard therapy-related systemic immunosuppression in glioblastoma for immunotherapy …
AA Stepanenko, AO Sosnovtseva, MP Valikhov… - Frontiers in …, 2024 - frontiersin.org
Despite significant advances in our knowledge regarding the genetics and molecular
biology of gliomas over the past two decades and hundreds of clinical trials, no effective …
biology of gliomas over the past two decades and hundreds of clinical trials, no effective …
FLASH radiotherapy sparing effect on the circulating lymphocytes in pencil beam scanning proton therapy: Impact of hypofractionation and dose rate
A Galts, A Hammi - Physics in Medicine & Biology, 2024 - iopscience.iop.org
Purpose. The sparing effect of ultra-high dose rate (FLASH) radiotherapy has been reported,
but its potential to mitigate depletion of circulating blood and lymphocytes (CL) has not been …
but its potential to mitigate depletion of circulating blood and lymphocytes (CL) has not been …