Parasitic diseases result in considerable human morbidity and mortality. The continuous
emergence and spread of new drug-resistant parasite strains is an obstacle to controlling …

The ensemble of aminoacyl tRNA synthetases is regarded as a key component of the
protein translation machinery. With the progressive increase in structure-based studies on …

Truncated versions of heavy-chain antibodies (HCAbs) from camelids, also termed
nanobodies, comprise only one-tenth the mass of conventional antibodies, yet retain similar …

Leishmaniasis is a group of neglected tropical diseases caused by at least 20 species of
Leishmania protozoa, which are spread by the bite of infected sandflies. There are three …

Background Treatment of parasitic diseases has been challenging due to evolution of drug
resistant parasites, and thus there is need to identify new class of drugs and drug targets …

Febrifugine, a natural alkaloid, exhibits specific anti-phytophthora activity; however, its mode
of action is unclear. In this study, halofuginone, a synthetic derivative of febrifugine, showed …

Abstract TriTryp diseases (Leishmaniasis, Human African Trypanosomiasis (HAT), and
Chagas disease) are devastating parasitic neglected tropical diseases (NTDs) that affect …

A new bisbenzylisoquinoline named as chondrofolinol (1) and four reported compounds (2–
5) were isolated and characterized from the roots of Berberis glaucocarpa Stapf. Anti …

Background Bioanalytical methods that enable rapid and high-detail characterization of
binding specificities and strengths of protein complexes with low sample consumption are …

Potent inhibitors of Trypanosoma brucei methionyl-tRNA synthetase were previously
designed using a structure-guided approach. Compounds 1 and 2 were the most active …