New insights into the pathophysiology and management of osteoporosis in patients with beta thalassaemia

E Voskaridou, E Terpos - British Journal of Haematology, 2004 - Wiley Online Library
Osteoporosis represents an important cause of morbidity in adult patients with thalassaemia
major (TM). The pathogenesis of osteoporosis in TM is multifactorial, and includes bone …

Bone disease and skeletal complications in patients with β thalassemia major

R Haidar, KM Musallam, AT Taher - Bone, 2011 - Elsevier
Increased survival in patients with β thalassemia major (TM) allowed for several
complications of the disease and its treatment to manifest, one of which is bone disease …

[PDF][PDF] Bone disease in thalassemia: a frequent and still unresolved problem

MG Vogiatzi, EA Macklin, EB Fung… - Journal of Bone and …, 2009 - Wiley Online Library
Adults with β thalassemia major frequently have low BMD, fractures, and bone pain. The
purpose of this study was to determine the prevalence of low BMD, fractures, and bone pain …

Bone disease in thalassemia: a molecular and clinical overview

P Wong, PJ Fuller, MT Gillespie, F Milat - Endocrine reviews, 2016 - academic.oup.com
Thalassemia bone disease is a common and severe complication of thalassemia—an
inherited blood disorder due to mutations in the α or β hemoglobin gene. In its more severe …

Endocrine function and bone disease during long‐term chelation therapy with deferasirox in patients with β‐thalassemia major

M Casale, S Citarella, A Filosa… - American journal of …, 2014 - Wiley Online Library
Iron overload in β‐thalassemia major (TM) typically results in iron‐induced cardiomyopathy,
liver disease, and endocrine complications. We examined the incidence and progression of …

Hematological diseases and osteoporosis

A Gaudio, A Xourafa, R Rapisarda, L Zanoli… - International Journal of …, 2020 - mdpi.com
Secondary osteoporosis is a common clinical problem faced by bone specialists, with a
higher frequency in men than in women. One of several causes of secondary osteoporosis is …

Evaluation of osseous changes in dental panoramic radiography of thalassemia patients using mandibular indexes and fractal size analysis

S Bayrak, D Göller Bulut, K Orhan, EA Sinanoğlu… - Oral radiology, 2020 - Springer
Objective This study aimed to evaluate the radiomorphometric indexes and fractal
dimension (FD) on dental panoramic radiography (DPR) of Thalassemia Major (TM) …

Osteoprotegerin and RANKL in the pathogenesis of thalassemia‐induced osteoporosis: new pieces of the puzzle

N Morabito, A Gaudio, A Lasco… - Journal of Bone and …, 2004 - academic.oup.com
Osteoporosis represents an important cause of morbidity in adult thalassemic patients, and
its pathogenesis has not, as yet, been completely clarified. In our study, we observed that …

[HTML][HTML] Hypogonadism in thalassemia major patients

S Srisukh, B Ongphiphadhanakul, P Bunnag - Journal of clinical & …, 2016 - Elsevier
Despite recent advances in iron chelation therapy, excess iron deposition in pituitary
gonadotropic cells remains one of the major problems in thalassemic patients …

Conversion of red bone marrow into yellow–Cause and mechanisms

O Gurevitch, S Slavin, AG Feldman - Medical hypotheses, 2007 - Elsevier
Marrow cavities in all the bones of newborn mammals contain active hematopoietic tissue,
known as red bone marrow. From the early postnatal period onwards, the hematopoietic …