Phytochemicals and regulation of NF-kB in inflammatory bowel diseases: an overview of in vitro and in vivo effects

LF Laurindo, ARO Santos, ACA Carvalho, MD Bechara… - Metabolites, 2023 - mdpi.com
Inflammatory bowel diseases (IBD) are chronic relapsing idiopathic inflammatory conditions
affecting the gastrointestinal tract. They are mainly represented by two forms, ulcerative …

Treatment effects of natural products on inflammatory bowel disease in vivo and their mechanisms: Based on animal experiments

Y Zhou, D Wang, W Yan - Nutrients, 2023 - mdpi.com
Inflammatory bowel disease (IBD) is a chronic, non-specific inflammatory disease of the
intestine that can be classified as ulcerative colitis (UC) and Crohn's disease (CD) …

Molecular docking identifies 1, 8-Cineole (Eucalyptol) as a novel PPARγ agonist that alleviates colon inflammation

B Venkataraman, S Almarzooqi, V Raj… - International journal of …, 2023 - mdpi.com
Inflammatory bowel disease, comprising Crohn's disease (CD) and ulcerative colitis (UC), is
often debilitating. The disease etiology is multifactorial, involving genetic susceptibility …

The role of thymoquinone in inflammatory response in chronic diseases

Y Liu, L Huang, MY Kim, JY Cho - International Journal of Molecular …, 2022 - mdpi.com
Anti-inflammatory therapies have been shown to be effective in the prevention of various
cardiovascular diseases, tumors, and cancer complications. Thymoquinone (TQ), the main …

Black Cumin Seed (Nigella sativa) in Inflammatory Disorders: Therapeutic Potential and Promising Molecular Mechanisms

HK Rashwan, S Mahgoub, NZ Abuelezz… - Drugs and Drug …, 2023 - mdpi.com
Inflammation is an essential defense mechanism against harmful stimuli. However,
uncontrolled inflammatory mechanisms culminate in disturbed responses that contribute to …

Recent Advances in Cell‐Based In Vitro Models to Recreate Human Intestinal Inflammation

MH Macedo, M Dias Neto, L Pastrana… - Advanced …, 2023 - Wiley Online Library
Inflammatory bowel disease causes a major burden to patients and healthcare systems,
raising the need to develop effective therapies. Technological advances in cell culture, allied …

Molecular mechanisms and signaling pathways of black cumin (Nigella sativa) and its active constituent, thymoquinone: a review

E Sadeghi, M Imenshahidi, H Hosseinzadeh - Molecular Biology Reports, 2023 - Springer
Background Nigella sativa and its main bioactive ingredient, thymoquinone, exhibit various
pharmacological activities, including neuroprotective, nephroprotective, cardioprotective …

Different dose of sucrose consumption divergently influences gut microbiota and PPAR-γ/MAPK/NF-κB pathway in DSS-induced colitis mice

X Zhang, B Zhang, B Peng, J Wang, Y Hu, R Wang… - Nutrients, 2022 - mdpi.com
Sugar reduction and sugar control are advocated and gaining popularity around the world.
Sucrose, as the widely consumed ingredient in our daily diet, has been reported a relation to …

Potential anticancer properties and mechanisms of thymoquinone in colorectal cancer

F Sheikhnia, V Rashidi, H Maghsoudi… - Cancer cell …, 2023 - Springer
Colorectal neoplasms are one of the deadliest diseases among all cancers worldwide.
Thymoquinone (TQ) is a natural compound of Nigella sativa that has been used in traditional …

Cis-nerolidol inhibits MAP kinase and NF-κB signaling pathways and prevents epithelial tight Junction dysfunction in Colon inflammation: in vivo and in Vitro studies

V Raj, B Venkataraman, SK Ojha, S Almarzooqi… - Molecules, 2023 - mdpi.com
Inflammation of the GI tract leads to compromised epithelial barrier integrity, which increases
intestine permeability. A compromised intestinal barrier is a critical event that leads to …