Despite the significant progress that has been made to eliminate vertical HIV infection, more
than 150,000 children were infected with HIV in 2019, emphasizing the continued need for …

During antiretroviral therapy (ART), most of the human immunodeficiency virus (HIV)
reservoirs persist in the B cell follicles (BCFs) of lymphoid tissue. Thus, for HIV cure …

ABSTRACT The “shock-and-kill” human immunodeficiency virus type 1 (HIV-1) cure strategy
involves latency reversal followed by immune-mediated clearance of infected cells. We have …

Human immunodeficiency virus (HIV-1) indefinitely persists, despite effective antiretroviral
therapy (ART), within a small pool of latently infected cells. These cells often display markers …

Globally, 1.8 million children are living with HIV-1. While antiretroviral therapy (ART) has
improved disease outcomes, it does not eliminate the latent HIV-1 reservoir. Interventions to …

Mother-to-child transmission of human immunodeficiency virus type 1 (HIV-1) continues to
cause new pediatric cases of infection through breastfeeding, a setting where it is not always …

Antiviral therapies with reduced frequencies of administration and high barriers to resistance
remain a major goal. For HIV, theories have proposed that viral-deletion variants, which …

Early antiretroviral therapy (ART) in HIV-infected infants generally fails to achieve a
sustained state of ART-free virologic remission, even after years of treatment. Our studies …

Mother-to-child transmission of human immunodeficiency virus type 1 (HIV-1) via
breastfeeding is responsible for nearly half of new infections of children with HIV. Although …

Pregnancy significantly elevates the risk of developing severe viral diseases, which can
have a detrimental effect on fetal development and increases maternal mortality. In addition …