Glioblastoma multiforme, because of its invasive nature, can be considered a disease of the
entire brain. Despite recent advances in surgery, radiotherapy and chemotherapy, current …

Malignant gliomas are relatively uncommon but lethal cancers. Despite recent research
efforts in cancer therapy, the prognosis of patients with malignant gliomas has remained …

Malignant gliomas are highly lethal cancers dependent on angiogenesis. Critical tumor
subpopulations within gliomas share characteristics with neural stem cells. We examined …

Glioblastoma is the most frequent and devastating primary malignant brain tumor in adults.
Surgery followed by standard radiotherapy with concomitant and adjuvant chemotherapy …

Vascular endothelial growth factor (VEGF) and epidermal growth factor receptor (EGFR)
signaling are established contributors to malignant glioma (MG) biology. We, therefore …

Glioblastoma multiformes (GBMs) are extensively heterogeneous at both cellular and
molecular levels. Current therapeutic strategies include targeting of key signaling molecules …

The prognosis of patients with glioblastoma, anaplastic astrocytoma, and anaplastic
oligodendroglioma remains poor despite standard treatment with radiotherapy and …

Glioblastoma, the most common primary malignant brain tumor among adults, is a highly
angiogenic and deadly tumor. Angiogenesis in glioblastoma, driven by hypoxia-dependent …

The concepts of stem cells being resistant to therapy, stem-like cells existing in brain tumors,
and these tumors initially responding to therapy followed by recurrence are well …

Pediatric high-grade gliomas (pHGG), including diffuse intrinsic pontine gliomas (DIPG), are
the leading cause of cancer-related death in children. While it is clear that surgery (if …