What is the sugar code?

HJ Gabius, M Cudic, T Diercks, H Kaltner… - …, 2022 - Wiley Online Library
A code is defined by the nature of the symbols, which are used to generate information‐
storing combinations (eg oligo‐and polymers). Like nucleic acids and proteins, oligo‐and …

Synthesis and biomedical applications of mucin mimic materials

VR Kohout, CL Wardzala, JR Kramer - Advanced drug delivery reviews, 2022 - Elsevier
Mucin glycoproteins are the major component of mucus and coat epithelial cell surfaces
forming the glycocalyx. The glycocalyx and mucus are involved in the transport of nutrients …

Small lectin ligands as a basis for applications in glycoscience and glycomedicine

PV Murphy, A Dhara, LS Fitzgerald, E Hever… - Chemical Society …, 2024 - pubs.rsc.org
Glycan recognition by lectins mediates important biological events. This Tutorial Review
aims to introduce lectin–ligand interactions and show how these molecular recognition …

Preparation and applications of artificial mucins in biomedicine

RE Detwiler, JR Kramer - Current Opinion in Solid State and Materials …, 2022 - Elsevier
Mucus is an essential barrier material that separates organisms from the outside world. This
slippery material regulates the transport of nutrients, drugs, gases, and pathogens toward …

The pleiotropic CLEC10A: Implications for harnessing this receptor in the tumor microenvironment

NL van der Meijs, MA Travecedo… - Expert Opinion on …, 2024 - Taylor & Francis
Introduction CLEC10A is a C-type lectin receptor that specifically marks the conventional
dendritic cell subsets two and three (cDC2 and DC3). It has a unique recognition profile of …

Synthesis and Thermodynamic Evaluation of Sialyl‐Tn MUC1 Glycopeptides Binding to Macrophage Galactose‐Type Lectin

R Ayyalasomayajula, I Boneva, D Ormaza… - …, 2024 - Wiley Online Library
Interactions between the tumor‐associated carbohydrate antigens of Mucin 1 (MUC1) and
the carbohydrate‐binding proteins, lectins, often lead to the creation of a pro‐tumor …

[HTML][HTML] Tumor-associated carbohydrate antigens of MUC1–Implication in cancer development

I Radziejewska - Biomedicine & Pharmacotherapy, 2024 - Elsevier
Glycosylation of cancerous epithelial MUC1 protein is specifically altered in comparison to
that which is presented by healthy cells. One of such changes is appearing tumor …

Tyrosine O-GalNAc Alters the Conformation and Proteolytic Susceptibility of APP Model Glycopeptides

YN Singh, D Ormaza, A Massetti… - ACS Chemical …, 2021 - ACS Publications
The amyloid-β precursor protein (APP) undergoes proteolytic cleavage by α-, β-, and γ-
secretases, to determine its fate in Alzheimer's disease (AD) pathogenesis. Recent findings …

[HTML][HTML] Preventative Cancer Vaccine-Elicited Human Anti-MUC1 Antibodies Have Multiple Effector Functions

ML McKeague, J Lohmueller, MT Dracz, N Saadallah… - Antibodies, 2024 - mdpi.com
Background/Objectives: Mucin-1 (MUC1) is a transmembrane glycoprotein that is
overexpressed and hypoglycosylated in premalignant and malignant epithelial cells …

Cell-surface glycan labeling and sensing

Y Li, L Wang, L Ding, H Ju - Targets, 2023 - mdpi.com
Cell-surface glycans are abundant and complex and play a critical role in maintaining
protein stability, regulating cell behavior, and participating in cell communication. Obtaining …