[HTML][HTML] Oxidative State in Cutaneous Melanoma Progression: A Question of Balance

M Benedusi, H Lee, Y Lim, G Valacchi - Antioxidants, 2024 - mdpi.com
Reactive oxygen species (ROS) are highly bioactive molecules involved not only in tissue
physiology but also in the development of different human conditions, including premature …

Computational single-cell methods for predicting cancer risk

AE Teschendorff - Biochemical Society Transactions, 2024 - portlandpress.com
Despite recent biotechnological breakthroughs, cancer risk prediction remains a formidable
computational and experimental challenge. Addressing it is critical in order to improve …

Single-Cell Informatics for Tumor Microenvironment and Immunotherapy

J Tian, X Bai, C Quek - International Journal of Molecular Sciences, 2024 - mdpi.com
Cancer comprises malignant cells surrounded by the tumor microenvironment (TME), a
dynamic ecosystem composed of heterogeneous cell populations that exert unique …

A Graph Curvature-Based Pipeline for Discovering Immune Checkpoint Response Biomarkers

JJ Bannon, CR Cantor, B Mishra - bioRxiv, 2024 - biorxiv.org
Immune checkpoint inhibitors (ICIs), also called immune checkpoint blockers, are a
promising category of targeted therapy for solid tumors. Predicting which patients will …

[HTML][HTML] ORCO: Ollivier-Ricci Curvature-Omics—an unsupervised method for analyzing robustness in biological systems

AK Simhal, C Weistuch, K Murgas, D Grange, J Zhu… - …, 2024 - pmc.ncbi.nlm.nih.gov
Although recent advanced sequencing technologies have improved the resolution of
genomic and proteomic data to better characterize molecular phenotypes, efficient …