Melatonin MT1 and MT2 receptor ligands have been vigorously explored for the last 4
decades. Inspection of approximately 80 publications in the field revealed that most …

Melatonin is a natural hormone primarily released by the pineal gland that regulates the
sleep-wake cycles. The diverse biological applications of melatonin, together with the need …

The tryptophan derivative melatonin is an evolutionary old molecule that is involved in a
pleiotropy of physiological functions. In humans, age‐related decline of circulating melatonin …

The long‐anticipated high‐resolution structures of the human melatonin G protein‐coupled
receptors MT1 and MT2, involved in establishing and maintaining circadian rhythm, were …

Anticancer drug conjugates are an emerging approach for future cancer treatment. Here, we
report a series of hybrid ligands merging the neurohormone melatonin with the approved …

Introduction The neurohormone melatonin (N-acetyl-5-methoxytryptamine) regulates
circadian rhythms exerting a variety of effects in the central nervous system and in periphery …

The search for melatonin receptor agonists formed the main part of melatonin medicinal
chemistry programs for the last three decades. In this short review, we summarize the two …

The two human melatonin receptors MT1 and MT2, which belong to the G protein-coupled
receptor (GPCR) family, are important drug targets with approved indications for circadian …

Drug conjugates of tamoxifen and melatonin linked through the amide side chain of
melatonin (4a, 4b) were reported as promising agents for future treatment of breast cancer …

The design of hybrid (chimeric) molecules containing two different pharmacophores
connected via a spacer (linker) is a promising approach to the functionalization of natural …