Formation of γ-H2AX in response to DNA double stranded breaks (DSBs) provides the basis
for a sensitive assay of DNA damage in human biopsies. The review focuses on the …

In the adult mammalian brain, newly generated neurons are continuously incorporated into
two networks: interneurons born in the subventricular zone migrate to the olfactory bulb …

DNA methylation has been traditionally viewed as a highly stable epigenetic mark in
postmitotic cells. However, postnatal brains appear to show stimulus-induced methylation …

Adult hypothalamic neurogenesis has recently been reported, but the cell of origin and the
function of these newborn neurons are unknown. Using genetic fate mapping, we found that …

Adult neurogenesis represents a striking example of structural plasticity in the mature brain.
Research on adult mammalian neurogenesis today focuses almost exclusively on two …

The hypothalamus is the central regulator of a broad range of homeostatic and instinctive
physiological processes, such as the sleep-wake cycle, food intake, and sexually dimorphic …

For translational cancer research, pre-clinical in-vivo studies using small animals have
become indispensable in bridging the gap between in-vitro cell experiments and clinical …

Glioblastoma (GBMs) is the most common and aggressive type of primary brain tumor in
adults with dismal prognosis despite radical surgical resection coupled with chemo-and …

Over the past several decades, the proliferation and integration of adult-born neurons into
existing hippocampal circuitry has been implicated in a wide range of behaviors, including …

Purpose In preclinical radiation research, it is challenging to localize soft tissue targets
based on cone beam computed tomography (CBCT) guidance. As a more effective method …