Therapy-induced polyploidization and senescence: Coincidence or interconnection?

E Sikora, J Czarnecka-Herok, A Bojko… - Seminars in cancer …, 2022 - Elsevier
Polyploid somatic cells have 'programmed'roles in normal development and stress
responses. Transient polyploidy states have been observed in several tumor types at early …

[HTML][HTML] Adipose tissue-to-breast cancer crosstalk: Comprehensive insights

Y Wu, X Li, Q Li, C Cheng, L Zheng - … et Biophysica Acta (BBA)-Reviews on …, 2022 - Elsevier
The review focuses on mechanistic evidence for the link between obesity and breast cancer.
According to the IARC study, there is sufficient evidence that obesity is closely related to a …

[HTML][HTML] Stem cells implanted with nanofibrous mats for injured endometrial regeneration and immune-microenvironment remodeling

L Zhou, H Wang, D Shen, J Xiang, N Yu, X He… - Materials Today Bio, 2023 - Elsevier
Severe endometrial injury caused by invasive uterine operation and/or endometritis often
results in intrauterine adhesions (IUAs), which are named Asherman's syndrome (AS) …

[HTML][HTML] Krüppel-like factors in breast cancer: Function, regulation and clinical relevance

J Zhang, G Li, L Feng, H Lu, X Wang - Biomedicine & Pharmacotherapy, 2020 - Elsevier
Breast cancer has accounted for the leading cause of cancer-related mortality among
women worldwide. Although the progress in its diagnosis and treatment has come at a …

Lipofilling in breast oncological surgery: a safe opportunity or risk for cancer recurrence?

F Piccotti, I Rybinska, E Scoccia, C Morasso… - International Journal of …, 2021 - mdpi.com
Lipofilling (LF) is a largely employed technique in reconstructive and esthetic breast surgery.
Over the years, it has demonstrated to be extremely useful for treatment of soft tissue defects …

Increase in IGF-1 expression in the injured infraorbital nerve and possible implications for orofacial neuropathic pain

S Sugawara, M Shinoda, Y Hayashi, H Saito… - International journal of …, 2019 - mdpi.com
Insulin-like growth factor-1 (IGF-1) is upregulated in the injured peripheral nerve bundle and
controls nociceptive neuronal excitability associated with peripheral nerve injury. Here, we …

Canine Bone Marrow-derived Mesenchymal Stem Cells: Genomics, Proteomics and Functional Analyses of Paracrine Factors*[S]

F Humenik, D Cizkova, S Cikos, L Luptakova… - Molecular & Cellular …, 2019 - ASBMB
Adult stem cells have become prominent candidates for treating various diseases in
veterinary practice. The main goal of our study was therefore to provide a comprehensive …

Whole-Genome Duplications in Evolution, Ontogeny, and Pathology: Complexity and Emergency Reserves

OV Anatskaya, AE Vinogradov - Molecular Biology, 2021 - Springer
Abstract Whole-genome duplication (WGD), or polyploidy, increases the amount of genetic
information in the cell. WGDs of whole organisms are found in all branches of eukaryotes …

[HTML][HTML] The clinical significance of CHEK1 in breast cancer: a high-throughput data analysis and immunohistochemical study

M Wu, JS Pang, Q Sun, Y Huang, JY Hou… - … journal of clinical and …, 2019 - ncbi.nlm.nih.gov
Breast cancer (BC) is a kind of malignant cancer that seriously threatens women's health.
Research scientists have found that BC occurs as the result of multiple effects of the external …

Review of preclinical and clinical studies of using cell‐based therapy for secondary lymphedema

CE Chen, NJ Chiang, CK Perng, H Ma… - Journal of Surgical …, 2020 - Wiley Online Library
Secondary lymphedema is associated with impaired lymph fluid drainage and remains
incurable. Alternatively, cell‐based therapy may pave the way for lymphedema treatment …