Lactic acid bacteria constitute a diverse group of industrially significant, safe microorganisms
that are primarily used as starter cultures and probiotics, and are also being developed as …

Nucleosides are valuable bioactive molecules, which display antiviral and antitumour
activities. Diverse types of prodrugs are designed to enhance their therapeutic efficacy …

In this work, a mono-and a bi-enzymatic analytical immobilized enzyme reactors (IMERs)
were developed as prototypes for biosynthetic purposes and their performances in the in …

Nowadays, pharmaceutical industry demands competitive and eco-friendly processes for
active pharmaceutical ingredients (APIs) manufacturing. In this context, enzyme and whole …

In recent years, glycosiltransferases have arisen as standard biocatalysts for the enzymatic
synthesis of a wide variety of natural and non-natural nucleosides. Such enzymatic …

β-Nucleosides are fundamental building blocks of biological systems and are widely used
as therapeutic agents for the treatment of cancer and viral infections, among others. In the …

The use of enzymes for the synthesis of nucleoside analogues offers several advantages
over multistep chemical methods, including chemo‐, regio‐and stereoselectivity as well as …

One of the major drawbacks of the industrial implementation of enzymatic processes is the
low operational stability of the enzymes under tough industrial conditions. In this respect, the …

Due to their similarity to natural counterparts, nucleic acid derivatives (nucleobases,
nucleosides, and nucleotides, among others) are interesting molecules for pharmaceutical …

Cladribine triphosphate is the active compound of the anti-cancer and multiple sclerosis
drug Mavenclad (cladribine). Biosynthesis of such non-natural deoxyribonucleotides is …