Inflammation is an immune response that works as a contained fire that is pre-emptively
sparked as a defensive process during infections or upon any kind of tissue insult, and that …

Rheumatoid arthritis (RA) is characterized by hyperplastic synovial pannus tissue, which
mediates destruction of cartilage and bone. Fibroblast-like synoviocytes (FLS) are a key …

Metabolomic studies of body fluids show that immune‐mediated inflammatory diseases such
as rheumatoid arthritis (RA) are associated with metabolic disruption. This is likely to reflect …

An increasing number of studies show how changes in intracellular metabolic pathways
alter tumor and immune cell function. However, little information about metabolic changes in …

Adipocytes account for the largest proportion among the cells that comprise breast tissue;
therefore, they are considered to be a critical cell type in the tumor microenvironment of …

Fibrosis is a pathological process characterized by excessive accumulation of connective
tissue components in an organ or tissue. Fibrosis is produced by deregulated wound …

Doxorubicin (DOX) is extensively applied in cancer therapy due to its efficacy in suppressing
cancer progression and inducing apoptosis. After its discovery, this chemotherapeutic agent …

Sphingolipids, which are components of cellular membranes and organ tissues, can be
synthesized or degraded to modulate cellular responses according to environmental cues …

Rheumatoid arthritis is characterized by synovial inflammation and irreversible bone
erosions, both highlighting the immense reciprocal relationship between the immune and …

Lysophosphatidylcholine (LPC) and lysophosphatidic acid (LPA), the most prominent
lysoglycerophospholipids, are emerging as a novel class of inflammatory lipids, joining …