[HTML][HTML] Mood disturbances in Parkinson's disease: From prodromal origins to application of animal models

S Hayley, F Vahid-Ansari, H Sun, PR Albert - Neurobiology of Disease, 2023 - Elsevier
Parkinson's disease (PD) is a complex illness with a constellation of environmental insults
and genetic vulnerabilities being implicated. Strikingly, many studies only focus on the …

Application of neurotoxin-induced animal models in the study of Parkinson's disease-related depression: profile and proposal

YK Mou, LN Guan, XY Yao, JH Wang… - Frontiers in Aging …, 2022 - frontiersin.org
Depression can be a non-motor symptom, a risk factor, and even a co-morbidity of
Parkinson's disease (PD). In either case, depression seriously affects the quality of life of PD …

Habenula as a possible target for treatment-resistant depression phenotype in Wistar Kyoto rats

A Korlatowicz, P Pabian, J Solich, M Kolasa… - Molecular …, 2023 - Springer
The mechanisms of treatment-resistant depression (TRD) are not clear and are difficult to
study. An animal model resembling human TRD is the Wistar Kyoto rat strain. In the present …

[HTML][HTML] The habenula in Parkinson's disease: anatomy, function, and implications for mood disorders-a narrative review

B Samanci, S Tan, S Michielse, ML Kuijf… - Journal of Chemical …, 2024 - Elsevier
ABSTRACT Parkinson's disease (PD), a widespread neurodegenerative disorder, often
coexists with mood disorders. Degeneration of serotonergic neurons in brainstem raphe …

Multi-level variations of lateral habenula in depression: A comprehensive review of current evidence

GM Zhang, HY Wu, WQ Cui, W Peng - Frontiers in psychiatry, 2022 - frontiersin.org
Despite extensive research in recent decades, knowledge of the pathophysiology of
depression in neural circuits remains limited. Recently, the lateral habenula (LHb) has been …

Serotonin/dopamine interaction: Electrophysiological and neurochemical evidence

P De Deurwaerdère, A Chagraoui… - Progress in brain …, 2021 - Elsevier
The interaction between serotonin (5-HT) and dopamine (DA) in the central nervous system
(CNS) plays an important role in the adaptive properties of living animals to their …

Activation of 5-HT6 Receptors in the Ventrolateral Orbital Cortex Produces Anti-Anxiodepressive Effects in a Rat Model of Neuropathic Pain

YL Zhao, HY Yi, SS Baba, YX Guo, XC Yuan… - Molecular …, 2025 - Springer
The comorbidity of anxiety and depression frequently occurs in patients with neuropathic
pain. The ventrolateral orbital cortex (VLO) plays a critical role in mediating neuropathic pain …

The Serotonin 4 Receptor Subtype: A Target of Particular Interest, Especially for Brain Disorders

V Sgambato - International Journal of Molecular Sciences, 2024 - mdpi.com
In recent years, particular attention has been paid to the serotonin 4 receptor, which is well
expressed in the brain, but also peripherally in various organs. The cerebral distribution of …

Chronic stimulation of the serotonergic 5-HT4 receptor modulates amyloid-beta-related impairments in synaptic plasticity and memory deficits in male rats

N Hashemi-Firouzi, S Shahidi, SS Asl - Brain Research, 2021 - Elsevier
Alzheimer's disease (AD) is a neurodegenerative disease characterized by memory decline
and impaired hippocampal synaptic plasticity. The serotonin 5-HT4 receptor is involved in …

Investigating affective neuropsychiatric symptoms in rodent models of Parkinson's disease

L Boi, G Fisone - International Review of Neurobiology, 2024 - Elsevier
Affective neuropsychiatric disorders such as depression, anxiety and apathy are among the
most frequent non-motor symptoms observed in people with Parkinson's disease (PD) …