Counter-regulatory renin-angiotensin system in hypertension: Review and update in the era of COVID-19 pandemic

H Chen, J Peng, T Wang, J Wen, S Chen… - Biochemical …, 2023 - Elsevier
Cardiovascular disease is the major cause of mortality and disability, with hypertension
being the most prevalent risk factor. Excessive activation of the renin-angiotensin system …

Evaluation of circulating plasma proteins in breast cancer using Mendelian randomisation

A Mälarstig, F Grassmann, L Dahl, M Dimitriou… - Nature …, 2023 - nature.com
Biomarkers for early detection of breast cancer may complement population screening
approaches to enable earlier and more precise treatment. The blood proteome is an …

Human genetic basis of severe or critical illness in COVID-19

XS Ji, B Chen, B Ze, WH Zhou - Frontiers in cellular and infection …, 2022 - frontiersin.org
Coronavirus Disease 2019 (COVID-19) caused by the novel severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2) has led to considerable morbidity and mortality …

Control of SARS-CoV-2 infection by MT1-MMP-mediated shedding of ACE2

X Guo, J Cao, JP Cai, J Wu, J Huang, P Asthana… - Nature …, 2022 - nature.com
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused a global
pandemic. Angiotensin-converting enzyme 2 (ACE2) is an entry receptor for SARS-CoV-2 …

Host genetic polymorphisms involved in long-term symptoms of COVID-19

W Udomsinprasert, N Nontawong… - Emerging Microbes & …, 2023 - Taylor & Francis
Host genetic polymorphisms are recognized as a critical determinant of diversity in clinical
symptoms of Coronavirus disease 2019 (COVID-19). Accordingly, this study aimed to …

CDK4/6 inhibitor palbociclib promotes SARS-CoV-2 cell entry by down-regulating SKP2 dependent ACE2 degradation

Y Xiao, Y Yan, L Chang, H Ji, H Sun, S Song, K Feng… - Antiviral Research, 2023 - Elsevier
Abstract Coronavirus disease 2019 (COVID-19) outbreak has become a global pandemic.
CDK4/6 inhibitor palbociclib was reported to be one of the top-scored repurposed drugs to …

P-selectin Facilitates SARS-CoV-2 Spike 1 Subunit Attachment to Vesicular Endothelium and Platelets

C Wang, S Wang, X Ma, X Yao, K Zhan… - ACS Infectious …, 2024 - ACS Publications
SARS-CoV-2 infection starts from the association of its spike 1 (S1) subunit with sensitive
cells. Vesicular endothelial cells and platelets are among the cell types that bind SARS-CoV …

Impact of ACE2 on the susceptibility and vulnerability to COVID-19

KG Pringle, LK Philp - Journal of Endocrinology, 2023 - joe.bioscientifica.com
Angiotensin-converting enzyme 2 (ACE2) is not only the viral receptor for the novel
coronavirus severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) but is also …

The genetic associations of COVID-19 on genitourinary symptoms

Z Chang, L An, M Lei, Z Song, J Deng, R Tang… - Frontiers in …, 2023 - frontiersin.org
Background Recently emerged reports indicated that patients with coronavirus disease
2019 (COVID-19) might experience novo genitourinary symptoms after discharge …

Were metabolic and other chronic diseases the driven onset epidemic forces of COVID-19 in Mexico?

G Acevedo-Sánchez, G Mora-Aguilera… - Frontiers in Public …, 2023 - frontiersin.org
The underline hypothesis of this study was that SARS-CoV-2 can infect individuals
regardless of health condition, sex, and age in opposition to the classical epidemiological …