Heme oxygenases are composed of two isozymes, Hmox1 and Hmox2, that catalyze the
degradation of heme to carbon monoxide (CO), ferrous iron, and biliverdin, the latter of …

Dynamic adjustments to neuronal energy supply in response to synaptic activity are critical
for neuronal function. Glial cells known as astrocytes have processes that ensheath most …

The brain possesses two intricate mechanisms that fulfill its continuous metabolic needs:
cerebral autoregulation, which ensures constant cerebral blood flow over a wide range of …

Carbon monoxide (CO) and hydrogen sulfide (H 2 S) used to be thought of simply as lethal
and (for H 2 S) smelly gaseous molecules; now they are known to have important signaling …

The diverse physiological actions of the “biologic gases,” O2, CO, NO, and H2S, have
attracted much interest. Initially viewed as toxic substances, CO, NO, and H2S play important …

Enhancement of cerebral blood flow by hypoxia is critical for brain function, but signaling
systems underlying its regulation have been unclear. We report a pathway mediating …

Carbon monoxide (CO) has been firmly established as an endogenous signaling molecule
with a variety of pathophysiological and pharmacological functions, including …

Though the existence of hydrogen sulfide (H 2 S) in biological tissues has been known for
over 300 years, it is the most recently appreciated of the gasotransmitters as a physiologic …

The repair of bone defects with biomaterials depends on a sufficient vascularization of the
implantation site. We analyzed the effect of pore size on the vascularization and …

Carbon monoxide (CO) is produced by heme oxygenase (HO)-catalyzed heme degradation
to CO, iron, and biliverdin. HO has two active isoforms, HO-1 (inducible) and HO-2 …