One in 10 persons in the world aged 40 years and older will develop the syndrome of
HFpEF (heart failure with preserved ejection fraction), the most common form of chronic …

Among the complications of diabetes, cardiovascular events and cardiac insufficiency are
considered two of the most important causes of death. Experimental and clinical evidence …

Natural products are mainly secondary metabolites produced by plants, microorganisms,
and animals, which are still abundant in modern drug discovery. Terpenoids are the most …

Acute lung injury (ALI)/acute respiratory distress syndrome (ARDS) is featured by intensive
inflammatory responses and oxidative stress, which lead to cytokine storms and pyroptosis …

S-glutathionylation and S-nitrosylation are reversible post-translational modifications on the
cysteine thiol groups of proteins, which occur in cells under physiological conditions and …

Chlorogenic acid is a bioactive compound ubiquitously present in the natural realm, lauded
for its salient anti-inflammatory and antioxidant attributes. It executes its anti-inflammatory …

Background Acute lung injury (ALI) is a complex pulmonary destructive disease with limited
therapeutic approaches. Hydnocarpin D (HD) is a flavonolignan isolated from Hydnocarpus …

The eye is an immune privileged tissue that insulates the visual system from local and
systemic immune provocation to preserve homeostatic functions of highly specialized retinal …

A series of diclofenac hybrid molecules were synthesized and evaluated for their NO-
inhibitory ability in LPS-induced RAW 264.7 macrophage cells. Among them, compound 1 …

Nobiletin, a polymethoxyflavone widely present in the peel of citrus fruits, has significant anti-
inflammatory activity. Autophagy plays a critical role in maintaining cell homeostasis by …