Organisms evolve in response to their natural environment. Consideration of natural
ecological parameters are thus of key importance for our understanding of an organism's …

DAF-16, the only forkhead box transcription factors class O (FoxO) homolog in
Caenorhabditis elegans, integrates signals from upstream pathways to elicit transcriptional …

The genetically tractable model organism Caenorhabditis elegans was first used to model
bacterial virulence in vivo a decade ago. Since then, great strides have been made in …

Chronic inflammation predisposes to aging-associated disease, but it is unknown whether
immunity regulation might be important for extending healthy lifespan. Here we show that in …

The genetically tractable model host Caenorhabditis elegans provides a valuable tool to
dissect host-microbe interactions in vivo. Pseudomonas aeruginosa and Staphylococcus …

Insulin/insulin-like growth factor (IGF)-1 signaling (IIS) pathway regulates aging in many
organisms, ranging from simple invertebrates to mammals, including humans. Many seminal …

The innate immune system represents an ancient host defence mechanism that protects
against invading microorganisms. An important class of immune effector molecules to fight …

Host genetic landscapes can shape microbiome assembly in the animal gut by contributing
to the establishment of distinct physiological environments. However, the genetic …

The nematode worm Caenorhabditis elegans comprises an ancestral immune system. C.
elegans recognizes and responds to viral, bacterial, and fungal infections. Components of …

The opportunistic pathogen Pseudomonas aeruginosa causes serious human infections, but
effective treatments and the mechanisms mediating pathogenesis remain elusive …