The workshop entitled 'Interventions to Slow Aging in Humans: Are We Ready?'was held in
Erice, Italy, on October 8–13, 2013, to bring together leading experts in the biology and …

Hematologic malignancies represent the fourth most frequently diagnosed cancer in
economically developed countries. In hematologic malignancies normal hematopoiesis is …

Nordihydroguaiaretic acid (NDGA) is a phenolic lignan obtained from Larrea tridentata, the
creosote bush found in Mexico and USA deserts, that has been used in traditional medicine …

Survivin is a well-established target in experimental cancer therapy. The molecule is over-
expressed in most human tumors, but hardly detectable in normal tissues. Multiple functions …

Apoptosis is a tightly controlled, coordinated cellular event responsible for inducing
programmed cell death to rid the body of defective or unfit cells. Inhibition of apoptosis is …

Midkine (MDK) expression is associated with the proliferation of many cancers, including
glioma. However, the upstream signaling that leads to MDK accumulation remains elusive …

Brain cancer is a highly lethal disease, especially devastating toward both the elderly and
children. This cancer has no therapeutics available to combat it, predominately due to the …

Childhood cancer is considered rare, corresponding to~ 3% of all malignant neoplasms in
the human population. The World Health Organization (WHO) reports a universal …

In 1997 for the first time, survivin was described by Amborsini et al. as an anti-apoptotic
protein. Subsequent studies revealed that survivin is a multifunctional protein that plays …

Kusunokinin, a lignan compound, inhibits cancer cell proliferation and induces apoptosis;
however, the role of kusunokinin is not fully understood. Here, we aimed to identify a target …