Ion channels are specialized multimeric proteins that underlie cell excitability. These
channels integrate with a variety of neuromuscular and biological functions. In nematodes …

Drugs that block voltage-gated sodium channels are efficacious in the management of
neuropathic pain. Accordingly, this class of ion channels has been a major focus of …

Ion channels are well recognized as important therapeutic targets for treating a number of
different pathophysiologies. Historically, however, development of drugs targeting this …

Interleukin-6 (IL-6) is a key mediator of inflammation. Inhibitors of IL-6 or of its signal
transducing receptor gp130 constitute a novel class of anti-inflammatory drugs, which raise …

Background and Purpose The neutral amino acid transporter B0AT1 (SLC6A19) has
recently been identified as a possible target to treat type 2 diabetes and related disorders …

The tarantula venom peptides ProTx-I and ProTx-II inhibit voltage-gated sodium channels by
shifting their voltage dependence of activation to a more positive potential, thus acting by a …

Drugs inhibiting voltage-gated sodium channels have long been used as analgesics,
beginning with the use of local anaesthetics for sensory blockade and then with the …

For every movement, heartbeat and thought, ion channels need to open and close. It is
therefore not surprising that their malfunctioning leads to serious diseases. Currently, only …

Many ion channels, including Nav1. 7, Cav1. 3, and Kv1. 3, are linked to human pathologies
and are important therapeutic targets. To develop efficacious and safe drugs, subtype …

Voltage-gated sodium channels (Nav1) transmit pain signals from peripheral nociceptive
neurons, and blockers of these channels have been shown to ameliorate a number of pain …