The nucleotide-binding domain and leucine-rich repeat protein 3 (NLRP3), an intracellular
signaling molecule that senses many environmental-and pathogen/host-derived factors, has …

Sickle cell disease is caused by a mutant form of hemoglobin that polymerizes under
hypoxic conditions, increasing rigidity, fragility, calcium influx-mediated dehydration, and …

Endogenous nitric oxide (NO) is an important mediator in the processes that control
biological clocks and circadian rhythms. The present study was designed to elucidate if NO …

Our previous studies with the use of non‐selective cyclooxygenase (COX) inhibitor,
indomethacin, demonstrated that prostanoids produced during endotoxaemia increase …

The effects of selective ((5, 5-dimethyl-3-(3-florophenyl)-4-(4-methylsulphonyl-2 (5H)-
furanon); DFU) and (N-(2-cyclohexyloxy-4-nitrophenyl)-methansulphonamide; NS 398)) or …

We examined whether nitric oxide (NO), derived from constitutive NO synthase (NOS) and/or
inducible NOS (iNOS), could contribute to endotoxin-induced inflammatory hyperalgesia via …

We have previously demonstrated that inhibition of vasodilator prostanoids, PGI2 and PGE2,
and nitric oxide (NO) synthesis by a selective cyclooxygenase-2 (COX-2) inhibitor, NS-398 …

Nitric oxide (NO) produced by inducible NO synthase (iNOS) is responsible for endotoxin‐
induced vascular hyporeactivity and hypotension resulting in multiple organ failure …

Increased production of nitric oxide (NO) and prostaglandins contribute to development of
hypotension during endotoxemia. We have previously demonstrated that endotoxemia …

Overproduction of reactive oxygen and nitrogen species leads to oxidative stress and
decreased total antioxidant capacity, which is responsible for high mortality from several …