J Sun, AR Warden, X Ding - Biomicrofluidics, 2019 - pubs.aip.org
With ever increasing drug resistance and emergence of new diseases, demand for new drug development is at an unprecedented urgency. This fact has led to extensive recent efforts to …
Establishing the 3D microscale organization of cells has numerous practical applications, such as in determining cell fate (eg, proliferation, migration, differentiation, and apoptosis) …
TV Nguyen, M Sleiman, T Moriarty, WG Herrick… - Biomaterials, 2014 - Elsevier
Tumor progression is coincident with mechanochemical changes in the extracellular matrix (ECM). We hypothesized that tumor stroma stiffening, alongside a shift in the ECM …
The dynamic control of the chemical concentration within droplets is required in numerous droplet microfluidic applications. Here, we propose an acoustofluidic method for the …
DW Lee, YS Choi, YJ Seo, MY Lee, SY Jeon… - Analytical …, 2014 - ACS Publications
Contemporary cancer therapy refers to treatment based on genetic abnormalities found in patient's tumor. However, this approach is faced with numerous challenges, including tumor …
Micro‐and nanotechnologies have emerged as potentially effective fabrication tools for addressing the challenges faced in tissue engineering and drug delivery. The ability to …
Tumor size is strongly correlated with breast cancer metastasis and patient survival. Increased tumor size contributes to hypoxic and metabolic gradients in the solid tumor and …
X Fan, Z Deng, Y Yan, VE Orel, A Shypko… - Bosnian Journal of …, 2022 - ncbi.nlm.nih.gov
With the continuous development of drug screening technology, new screening methodologies and technologies are constantly emerging, driving drug screening into rapid …
M Singh, DA Close, S Mukundan… - Assay and drug …, 2015 - liebertpub.com
Despite significant investments in cancer research and drug discovery/development, the rate of new cancer drug approval is≤ 5% and most cases of metastatic cancer remain incurable …