Microfluidics for cell-based high throughput screening platforms—A review

G Du, Q Fang, JMJ den Toonder - Analytica chimica acta, 2016 - Elsevier
In the last decades, the basic techniques of microfluidics for the study of cells such as cell
culture, cell separation, and cell lysis, have been well developed. Based on cell handling …

Recent advances in microfluidics for drug screening

J Sun, AR Warden, X Ding - Biomicrofluidics, 2019 - pubs.aip.org
With ever increasing drug resistance and emergence of new diseases, demand for new drug
development is at an unprecedented urgency. This fact has led to extensive recent efforts to …

Gelatin methacrylate as a promising hydrogel for 3D microscale organization and proliferation of dielectrophoretically patterned cells

J Ramón-Azcón, S Ahadian, R Obregón… - Lab on a Chip, 2012 - pubs.rsc.org
Establishing the 3D microscale organization of cells has numerous practical applications,
such as in determining cell fate (eg, proliferation, migration, differentiation, and apoptosis) …

Sorafenib resistance and JNK signaling in carcinoma during extracellular matrix stiffening

TV Nguyen, M Sleiman, T Moriarty, WG Herrick… - Biomaterials, 2014 - Elsevier
Tumor progression is coincident with mechanochemical changes in the extracellular matrix
(ECM). We hypothesized that tumor stroma stiffening, alongside a shift in the ECM …

Acoustofluidic generation of droplets with tunable chemical concentrations

J Park, G Destgeer, M Afzal, HJ Sung - Lab on a Chip, 2020 - pubs.rsc.org
The dynamic control of the chemical concentration within droplets is required in numerous
droplet microfluidic applications. Here, we propose an acoustofluidic method for the …

High-throughput screening (HTS) of anticancer drug efficacy on a micropillar/microwell chip platform

DW Lee, YS Choi, YJ Seo, MY Lee, SY Jeon… - Analytical …, 2014 - ACS Publications
Contemporary cancer therapy refers to treatment based on genetic abnormalities found in
patient's tumor. However, this approach is faced with numerous challenges, including tumor …

Development of functional biomaterials with micro‐and nanoscale technologies for tissue engineering and drug delivery applications

H Bae, H Chu, F Edalat, JM Cha, S Sant… - Journal of tissue …, 2014 - Wiley Online Library
Micro‐and nanotechnologies have emerged as potentially effective fabrication tools for
addressing the challenges faced in tissue engineering and drug delivery. The ability to …

Three-dimensional breast cancer models mimic hallmarks of size-induced tumor progression

M Singh, S Mukundan, M Jaramillo, S Oesterreich… - Cancer research, 2016 - AACR
Tumor size is strongly correlated with breast cancer metastasis and patient survival.
Increased tumor size contributes to hypoxic and metabolic gradients in the solid tumor and …

[HTML][HTML] Application of microfluidic chips in anticancer drug screening

X Fan, Z Deng, Y Yan, VE Orel, A Shypko… - Bosnian Journal of …, 2022 - ncbi.nlm.nih.gov
With the continuous development of drug screening technology, new screening
methodologies and technologies are constantly emerging, driving drug screening into rapid …

Production of uniform 3D microtumors in hydrogel microwell arrays for measurement of viability, morphology, and signaling pathway activation

M Singh, DA Close, S Mukundan… - Assay and drug …, 2015 - liebertpub.com
Despite significant investments in cancer research and drug discovery/development, the rate
of new cancer drug approval is≤ 5% and most cases of metastatic cancer remain incurable …