Biomolecular interactions are at the base of all physical processes within living organisms;
the study of these interactions has led to the development of a plethora of different methods …

Molecular motors are machines essential for life since they convert chemical energy into
mechanical work. However, the precise mechanism by which nucleotide binding, catalysis …

Heat shock proteins (HSPs) are ubiquitous polypeptides expressed in all living organisms
that participate in several basic cellular processes, including protein folding, from which their …

BiP (immunoglobulin heavy‐chain binding protein) is a Hsp70 monomeric ATPase motor
that plays broad and crucial roles in maintaining proteostasis inside the cell. Structurally, BiP …

Background Intestinal ischemia-reperfusion (II/R) injury is a common clinical emergency with
high morbidity and mortality. Given the absence of efficacious prophylactic and therapeutic …

The distance to the transition state (x‡) is an important parameter for understanding the
energy landscape of chemical reactions. In protein folding, x‡ represents the distance to the …

Photodynamic therapy is a non-invasive method where light activates a photosensitizer
bound to cancer cells, generating reactive oxygen species and resulting in cell death. This …

BiP es una chaperona perteneciente a la familia Hsp70 (Heat shock protein 70) que está
involucrada en la regulación de importantes procesos biológicos como la síntesis …

This thesis studied the Guanylate Kinase (GK) enzyme, which catalyzes the reaction of ATP
into ADP, using nano-rheological techniques. A unique experimental setup was created in …