The aryl hydrocarbon receptor (AhR), discovered 46 years ago, is a transcript factor member
of the basic helix-loop-helix Per-ARNT-SIM (bHLH-PAS) family deeply implicated in health …

Osteoporosis is the most common metabolic skeletal disease. It is characterized by the
deterioration of the skeletal microarchitecture and bone loss, leading to ostealgia, and even …

The antagonistic pleiotropy hypothesis is a well-known evolutionary theory to explain the
aging process. It proposes that while a particular gene may possess beneficial effects during …

Periodontitis is a periodontal inflammatory condition that results from disrupted periodontal
host–microbe homeostasis, manifested by the destruction of tooth-supporting structures …

Aryl hydrocarbon receptor (AHR) is a ligand-dependent transcription factor. 2, 3, 7, 8-
tetrachlorodibenzo-p-dioxin (TCDD) is a classical exogenous synthetic ligand of AHR that …

Introduction Rheumatoid arthritis (RA), which affects nearly 1% of the world's population, is a
debilitating autoimmune disease. Bone erosion caused by periarticular osteopenia and …

The aryl hydrocarbon receptor (AhR) is a versatile environmental sensor and transcription
factor found throughout the body, responding to a wide range of small molecules originating …

Chronic kidney disease (CKD) induces several systemic effects, including the accumulation
and production of uremic toxins responsible for the activation of various harmful processes …

Patients with chronic kidney disease (CKD) often experience a high accumulation of protein-
bound uremic toxins (PBUTs), specifically indoxyl sulfate (IS) and p-cresyl sulfate (pCS). In …

Rheumatoid arthritis (RA) is an autoimmune disease, in which the inflammatory processes
involve the skeletal system and there is marked destruction of the bones and the …