Depressive disorders: Treatment failures and poor prognosis over the last 50 years

TP Blackburn - Pharmacology research & perspectives, 2019 - Wiley Online Library
Depression like many diseases is pleiotropic but unlike cancer and Alzheimer's disease for
example, is still largely stigmatized and falls into the dark shadows of human illness. The …

Case finding and screening clinical utility of the Patient Health Questionnaire (PHQ-9 and PHQ-2) for depression in primary care: a diagnostic meta-analysis of 40 …

AJ Mitchell, M Yadegarfar, J Gill, B Stubbs - BJPsych open, 2016 - cambridge.org
BackgroundThe Patient Health Questionnaire (PHQ) is the most commonly used measure to
screen for depression in primary care but there is still lack of clarity about its accuracy and …

Depression as a modifiable factor to decrease the risk of dementia

OP Almeida, GJ Hankey, BB Yeap, J Golledge… - Translational …, 2017 - nature.com
Depression is an accepted risk factor for dementia, but it is unclear if this relationship is
causal. This study investigated whether dementia associated with depression decreases …

[HTML][HTML] First do no harm: Interventions during childbirth

L Jansen, M Gibson, BC Bowles… - The Journal of perinatal …, 2013 - ncbi.nlm.nih.gov
Although medical and technological advances in maternity care have drastically reduced
maternal and infant mortality, these interventions have become commonplace if not routine …

[HTML][HTML] National trends in antidepressant, benzodiazepine, and other sedative-hypnotic treatment of older adults in psychiatric and primary care

DT Maust, FC Blow, IR Wiechers… - The Journal of …, 2017 - legacy.psychiatrist.com
Objective: To describe how use of antidepressants, benzodiazepines, and other
anxiolytic/sedative-hypnotics among older adults (age≥ 65 years) has changed over time …

Psychotropic use and associated neuropsychiatric symptoms among patients with dementia in the USA

DT Maust, KM Langa, FC Blow… - International journal of …, 2017 - Wiley Online Library
Objective To determine the national prevalence of psychotropic use and association with
neuropsychiatric symptoms among patients with dementia. Methods Participants diagnosed …

Validity of the patient health questionnaire-2 (PHQ-2) for the detection of depression in primary care in Colombia

O Scoppetta, CA Cassiani-Miranda… - Journal of affective …, 2021 - Elsevier
Background The PHQ-2 is a screening test for major depressive disorder (MDD) derived
from PHQ-9, which has shown to be useful in the detection of cases of clinical significance in …

Heterogeneity in the prognosis of major depression: from the common cold to a highly debilitating and recurrent illness

L Lorenzo-Luaces - Epidemiology and Psychiatric Sciences, 2015 - cambridge.org
Two different and seemingly competing views on the diagnosis of major depressive disorder
(MDD) exist. The first is that the diagnosis conflates adaptive sadness reactions with …

Trends in central nervous system–active polypharmacy among older adults seen in outpatient care in the United States

DT Maust, LB Gerlach, A Gibson, HC Kales… - JAMA internal …, 2017 - jamanetwork.com
Methods| This analysis used data from the 2004 through 2013 National Ambulatory Medical
Care Survey (NAMCS), an annual survey of office-based physicians. 2 We limited our …

[HTML][HTML] Does depression in mid-life predispose to greater cognitive decline in later life in the Whitehall II cohort?

LI Sinclair, HA Ball, BM Bolea-Alamanac - Journal of Affective Disorders, 2023 - Elsevier
Background Later-life depression appears to have different symptomatology and possibly
underlying pathology to younger adults. Depression is linked to dementia but whether it is a …