Abstract Growth differentiation factor 15 (GDF15) is a member of the TGFβ superfamily
whose expression is increased in response to cellular stress and disease as well as by …

Nausea and vomiting of pregnancy (NVP) is a common condition that affects as many as
70% of pregnant women. Although no consensus definition is available for hyperemesis …

GDF15, a hormone acting on the brainstem, has been implicated in the nausea and vomiting
of pregnancy, including its most severe form, hyperemesis gravidarum (HG), but a full …

Nausea and vomiting are common gastrointestinal complaints that can be triggered by
diverse emetic stimuli through central and/or peripheral nervous systems. Both nausea and …

GDF15 is a cell activation and stress response cytokine of the glial cell line–derived
neurotrophic factor family within the TGF-β superfamily. It acts through a recently identified …

GDF15 and its receptor GFRAL/RET form a non-homeostatic system that regulates food
intake and body weight in preclinical species. Here, we describe a GDF15 analog …

Body weight and adiposity represent biologically controlled parameters that are influenced
by a combination of genetic, developmental and environmental variables. Although the …

GDF15 has recently gained scientific and translational prominence with the discovery that its
receptor is a GFRAL-RET heterodimer of which GFRAL is expressed solely in the hindbrain …

Nausea and vomiting of pregnancy (NVP) is a common condition that affects up to 70% of
pregnant women. Hyperemesis gravidarum (HG) is considered the serious form of NVP …

GDF15 regulates its anorexic effects through the hindbrain area postrema (AP) and nucleus
of the solitary tract (NTS) neurons where its receptor, glial-derived neurotrophic factor …