PRDM9 and its role in genetic recombination
K Paigen, PM Petkov - Trends in Genetics, 2018 - cell.com
PRDM9 is a zinc finger protein that binds DNA at specific locations in the genome where it
trimethylates histone H3 at lysines 4 and 36 at surrounding nucleosomes. During meiosis in …
trimethylates histone H3 at lysines 4 and 36 at surrounding nucleosomes. During meiosis in …
Trajectory of livestock genomics in South Asia: a comprehensive review
Livestock plays a central role in sustaining human livelihood in South Asia. There are
numerous and distinct livestock species in South Asian countries. Several of them have …
numerous and distinct livestock species in South Asian countries. Several of them have …
PRDM9, a driver of the genetic map
C Grey, F Baudat, B de Massy - PLoS genetics, 2018 - journals.plos.org
During meiosis, maternal and paternal chromosomes undergo exchanges by homologous
recombination. This is essential for fertility and contributes to genome evolution. In many …
recombination. This is essential for fertility and contributes to genome evolution. In many …
Variation in recombination rate and its genetic determinism in sheep populations
M Petit, JM Astruc, J Sarry, L Drouilhet, S Fabre… - Genetics, 2017 - academic.oup.com
Recombination is a complex biological process that results from a cascade of multiple
events during meiosis. Understanding the genetic determinism of recombination can help to …
events during meiosis. Understanding the genetic determinism of recombination can help to …
Cataloging Human PRDM9 Allelic Variation Using Long-Read Sequencing Reveals PRDM9 Population Specificity and Two Distinct Groupings of Related Alleles
The PRDM9 protein determines sites of meiotic recombination in humans by directing
meiotic DNA double-strand breaks to specific loci. Targeting specificity is encoded by a long …
meiotic DNA double-strand breaks to specific loci. Targeting specificity is encoded by a long …
The consequences of sequence erosion in the evolution of recombination hotspots
I Tiemann-Boege, T Schwarz… - … Transactions of the …, 2017 - royalsocietypublishing.org
Meiosis is initiated by a double-strand break (DSB) introduced in the DNA by a highly
controlled process that is repaired by recombination. In many organisms, recombination …
controlled process that is repaired by recombination. In many organisms, recombination …
Construction of PRDM9 allele-specific recombination maps in cattle using large-scale pedigree analysis and genome-wide single sperm genomics
PRDM 9 contributes to hybrid sterility and species evolution. However, its role is to be
confirmed in cattle, a major domesticated livestock species. We previously found an …
confirmed in cattle, a major domesticated livestock species. We previously found an …
Evolutionary dynamics of meiotic recombination hotspots regulator PRDM9 in bovids
Hybrid sterility or reproductive isolation in mammals has been attributed to allelic
incompatibilities in a DNA-binding protein PRDM9. Not only is PRDM9 exceptional in being …
incompatibilities in a DNA-binding protein PRDM9. Not only is PRDM9 exceptional in being …
Evolution of the recombination regulator PRDM9 in minke whales
Background PRDM9 is a key regulator of meiotic recombination in most metazoans,
responsible for reshuffling parental genomes. During meiosis, the PRDM9 protein …
responsible for reshuffling parental genomes. During meiosis, the PRDM9 protein …
[PDF][PDF] Emerging evidence for clinical significance of histone methyltransferase PRDM9 in reproductive system and cancer development.
240 possible expression of this gene in other locations and having clinical significance in
reproductive and cancer biology fields. In this review, we summarize the current knowledge …
reproductive and cancer biology fields. In this review, we summarize the current knowledge …