Molecular mechanisms of transgenerational epigenetic inheritance

MH Fitz-James, G Cavalli - Nature Reviews Genetics, 2022 - nature.com
Increasing evidence indicates that non-DNA sequence-based epigenetic information can be
inherited across several generations in organisms ranging from yeast to plants to humans …

Emerging evidence that the mammalian sperm epigenome serves as a template for embryo development

A Lismer, S Kimmins - Nature communications, 2023 - nature.com
Although more studies are demonstrating that a father's environment can influence child
health and disease, the molecular mechanisms underlying non-genetic inheritance remain …

Obesity II: establishing causal links between chemical exposures and obesity

JJ Heindel, S Howard, K Agay-Shay, JP Arrebola… - Biochemical …, 2022 - Elsevier
Obesity is a multifactorial disease with both genetic and environmental components. The
prevailing view is that obesity results from an imbalance between energy intake and …

Environmentally induced epigenetic transgenerational inheritance of disease

EE Nilsson, I Sadler-Riggleman… - Environmental …, 2018 - academic.oup.com
Ancestral environmental exposures such as toxicants, abnormal nutrition or stress can
promote the epigenetic transgenerational inheritance of disease and phenotypic variation …

Epigenetic inheritance and reproductive mode in plants and animals

D Anastasiadi, CJ Venney, L Bernatchez… - Trends in Ecology & …, 2021 - cell.com
Epigenetic inheritance is another piece of the puzzle of nongenetic inheritance, although the
prevalence, sources, persistence, and phenotypic consequences of heritable epigenetic …

Sperm RNA code programmes the metabolic health of offspring

Y Zhang, J Shi, M Rassoulzadegan, F Tuorto… - Nature Reviews …, 2019 - nature.com
Mammalian sperm RNA is increasingly recognized as an additional source of paternal
hereditary information beyond DNA. Environmental inputs, including an unhealthy diet …

An integrative framework for understanding the mechanisms and multigenerational consequences of transgenerational plasticity

AM Bell, JK Hellmann - Annual Review of Ecology, Evolution …, 2019 - annualreviews.org
Transgenerational plasticity (TGP) occurs when the environment experienced by a parent
influences the development of their offspring. In this article, we develop a framework for …

[HTML][HTML] Environmental obesogens and their impact on susceptibility to obesity: new mechanisms and chemicals

RJ Egusquiza, B Blumberg - Endocrinology, 2020 - academic.oup.com
The incidence of obesity has reached an all-time high, and this increase is observed
worldwide. There is a growing need to understand all the factors that contribute to obesity to …

A decade of exploring the mammalian sperm epigenome: paternal epigenetic and transgenerational inheritance

A Champroux, J Cocquet, J Henry-Berger… - Frontiers in Cell and …, 2018 - frontiersin.org
The past decade has seen a tremendous increase in interest and progress in the field of
sperm epigenetics. Studies have shown that chromatin regulation during male germline …

Targeting histone deacetylases for cancer therapy: Trends and challenges

T Liang, F Wang, RM Elhassan, Y Cheng… - … Pharmaceutica Sinica B, 2023 - Elsevier
Dysregulation of histone deacetylases (HDACs) is closely related to tumor development and
progression. As promising anticancer targets, HDACs have gained a great deal of research …