Role of estrogen receptors in health and disease

P Chen, B Li, L Ou-Yang - Frontiers in endocrinology, 2022 - frontiersin.org
Estrogen receptors (ERs) regulate multiple complex physiological processes in humans.
Abnormal ER signaling may result in various disorders, including reproductive system …

Lung cancer in never smokers—a different disease

S Sun, JH Schiller, AF Gazdar - Nature reviews cancer, 2007 - nature.com
Although most lung cancers are a result of smoking, approximately 25% of lung cancer
cases worldwide are not attributable to tobacco use, accounting for over 300,000 deaths …

Sex and gender differences in lung disease

P Silveyra, N Fuentes, DE Rodriguez Bauza - Lung Inflammation in Health …, 2021 - Springer
Sex differences in the anatomy and physiology of the respiratory system have been widely
reported. These intrinsic sex differences have also been shown to modulate the …

[HTML][HTML] Lung cancer in non-smokers

S Dubin, D Griffin - Missouri medicine, 2020 - ncbi.nlm.nih.gov
Lung cancer is the leading cause of cancer death worldwide and the third most common
cancer following breast and prostate. 1 As expected, the primary factor leading to lung …

It's all about sex: gender, lung development and lung disease

MA Carey, JW Card, JW Voltz, SJ Arbes… - Trends in Endocrinology …, 2007 - cell.com
Accumulating evidence suggests that gender affects the incidence, susceptibility and
severity of several lung diseases. Gender also influences lung development and physiology …

Phenotypes, risk factors, and mechanisms of adult‐onset asthma

P Ilmarinen, LE Tuomisto… - Mediators of …, 2015 - Wiley Online Library
Asthma is a heterogeneous disease with many phenotypes, and age at disease onset is an
important factor in separating the phenotypes. Genetic factors, atopy, and early respiratory …

Estrogen receptor α and β are prognostic factors in non–small cell lung cancer

H Kawai, A Ishii, K Washiya, T Konno, H Kon… - Clinical Cancer …, 2005 - AACR
Purpose: Estrogen receptor-α (ER-α) and-β (ER-β) play important roles in the
carcinogenesis of breast tumors. Similarly, there have been several reports of ER …

What pharmacologists can learn from recent advances in estrogen signalling

JÅ Gustafsson - Trends in pharmacological sciences, 2003 - cell.com
The discovery of the second estrogen receptor (ER) in 1995 surprised many
endocrinologists and resulted in some scepticism regarding its physiological importance …

Sex differences in airway disease: estrogen and airway surface liquid dynamics

BJ Harvey, NG McElvaney - Biology of sex Differences, 2024 - Springer
Biological sex differences exist for many airway diseases in which females have either
worse or better health outcomes. Inflammatory airway diseases such as cystic fibrosis (CF) …

Airborne urban particles (Milan winter-PM2. 5) cause mitotic arrest and cell death: Effects on DNA, mitochondria, AhR binding and spindle organization

M Gualtieri, J Øvrevik, S Mollerup, N Asare… - Mutation Research …, 2011 - Elsevier
Airborne particulate matter (PM) is considered to be an important contributor to lung
diseases. In the present study we report that Milan winter-PM2. 5 inhibited proliferation in …