Merkel cell carcinoma (MCC) is an aggressive skin malignancy with two distinct etiologies.
The first, which accounts for the highest proportion, is caused by Merkel cell polyomavirus …

In mammals, B cells strictly segregate proliferation from somatic mutation as they develop
within the bone marrow and then mature through germinal centers (GCs) in the periphery …

Background Endometriosis is a common, complex disorder which is underrecognized and
subject to prolonged delays in diagnosis. It is accompanied by significant changes in the …

There are numerous mechanisms by which glioblastoma cells evade immunological
detection, underscoring the need for strategic combinatorial treatments to achieve …

Despite advancements in understanding the pathophysiology of Multiple Myeloma (MM), the
cause of rapid progressing disease in a subset of patients is still unclear. MM's progression …

In the skin, Trypanosoma brucei colonises the subcutaneous white adipose tissue, and is
proposed to be competent for forward transmission. The interaction between parasites …

Although absence of interleukin-7 (IL-7) signaling completely abrogates T and B
lymphopoiesis in mice, patients with severe combined immunodeficiency caused by …

Lymphocytes can heavily influence intestinal health, but resolving intestinal lymphocyte
function is challenging as the intestine contains a vastly heterogeneous mixture of cells. Pigs …

Elimination of autoreactive developing B cells is an important mechanism to prevent
autoantibody production. However, how B cell receptor (BCR) signaling triggers apoptosis of …

Leukemia can arise at various stages of the hematopoietic differentiation hierarchy, but the
impact of developmental arrest on drug sensitivity is unclear. Applying network-based …