Vascular and lymphatic malformations represent a challenge for clinicians. The identification
of inherited and somatic mutations in important signaling pathways, including the PI3K …

Inflammation is an evolutionary process that allows survival against acute infection or injury.
Inflammation is also a pathophysiological condition shared by numerous chronic diseases …

Vascular malformations are inborn errors of vascular morphogenesis and consist of
localized networks of abnormal blood and/or lymphatic vessels with weak endothelial cell …

Significance: Generalized lymphatic anomaly and Gorham–Stout disease are extremely rare
diseases with severe symptoms and poor prognosis. The etiology and clinical presentation …

Vascular anomalies, characterized by the abnormal development or growth of blood and/or
lymphatic vessels, comprise a spectrum of diseases that have a wide range of complications …

Vascular anomalies represent a diverse group of disorders classified broadly as
malformations or tumors and include the second most common hereditary bleeding disorder …

Complex lymphatic anomalies (CLA) are congenital diseases of the lymphatic circulation
system that are associated with significant morbidity and early mortality. While guidelines for …

Abstract Background Sturge-Weber syndrome is a rare neurovascular disorder associated
with capillary malformation, seizures, cognitive impairments, and stroke-like episodes …

Introduction Patients with congenital vascular malformations often suffer from an impaired
quality of life (QoL) because of pain and functional disabilities. Previous studies have shown …

Sirolimus is the first drug to show efficacy in the treatment of patients with complicated
vascular anomalies. The current study expands on the evolution of a PK model-based …