Hereditary Angioedema Hereditary angioedema is a rare genetic disease that may include
recurrent attacks of cutaneous angioedema, severe abdominal pain, and airway …

Excessive enzyme activity often has pathological consequences. This for example is the
case in thrombosis and hereditary angioedema, where serine proteases of the coagulation …

Abstract C1 inhibitor (C1Inh) deficiency is responsible for hereditary angioedema (C1‐INH‐
HAE) and caused by variants of the SERPING1/C1INH/C1NH gene. C1Inh is the major …

Appropriate activation of coagulation requires a balance between procoagulant and
anticoagulant proteins in blood. Loss in this balance leads to hemorrhage and thrombosis. A …

Hereditary angioedema (HAE) is becoming much more genetically complex than was
initially considered. Thus, the role of HAE genetics is expanding beyond research …

Hereditary angioedema with C1 Inhibitor deficiency (C1-INH-HAE) is caused by a
constellation of variants of the SERPING1 gene (n= 809; 1,494 pedigrees), accounting for …

Hereditary angioedema (HAE) is an autosomal dominant disorder caused by a mutation in
the C1 esterase inhibitor gene. HAE affects 1/50,000 people worldwide. Three main types of …

Hereditary angioedema (HAE) is an uncommon genetic disorder characterized by recurrent
episodes of edema involving subcutaneous tissue and submucosa. The pathogenesis of …

Plasminogen activation is essential for fibrinolysis—the breakdown of fibrin polymers in
blood clots. Besides this important function, plasminogen activation participates in a wide …

Hereditary angioedema due to C1 inhibitor deficiency (C1-INH-HAE) is a rare and life-
threatening condition characterized by recurrent localized edema. We conducted a …