Genomic DNA is folded into loops and topologically associating domains (TADs), which
serve important structural and regulatory roles. It has been proposed that these genomic …

The four-dimensional nucleome (4DN) consortium studies the architecture of the genome
and the nucleus in space and time. We summarize progress by the consortium and highlight …

INTRODUCTION Our understanding of the pathophysiology of psychiatric disorders,
including autism spectrum disorder (ASD), schizophrenia (SCZ), and bipolar disorder (BD) …

Abstract Analysis of molecular aberrations across multiple cancer types, known as pan-
cancer analysis, identifies commonalities and differences in key biological processes that …

Abstract Cornelia de Lange syndrome (CdLS) is an archetypical genetic syndrome that is
characterized by intellectual disability, well-defined facial features, upper limb anomalies …

The cohesin complex has an essential role in maintaining genome organization. However,
its role in gene regulation remains largely unresolved. Here we report that the cohesin …

Fertilization triggers assembly of higher‐order chromatin structure from a condensed
maternal and a naïve paternal genome to generate a totipotent embryo. Chromatin loops …

Orofacial clefts are common birth defects and can occur as isolated, nonsyndromic events or
as part of Mendelian syndromes. There is substantial phenotypic diversity in individuals with …

Embryonic stem cells and induced pluripotent stem cells hold great promise for regenerative
medicine. These cells can be propagated in culture in an undifferentiated state but can be …

Transcription factors control cell-specific gene expression programs through interactions
with diverse coactivators and the transcription apparatus. Gene activation may involve DNA …