Cytokines are molecular messengers that allow the cells of the immune system to
communicate with one another to generate a coordinated, robust, but self-limited response …

IL6 is a pleiotropic cytokine that is made in response to perturbations in homeostasis. IL6
becomes elevated in the acute response to host injury and can activate immune cells, direct …

In the late 1960s, the essential role of T cells in antibody production was reported. This led to
our hypothesis that T-cell-derived soluble factors would have to be involved in the activation …

The family of cytokines signalling through the common receptor subunit gp130 comprises
interleukin (IL)-6, IL-11, leukaemia inhibitory factor, oncostatin M, ciliary neurotrophic factor …

▪ Abstract Receptors for most interleukins and cytokines that regulate immune and
hematopoietic systems belong to the class I cytokine receptor family. These molecules form …

▪ Abstract This essay summarizes my 40 years of research in immunology. As a young
physician, I encountered a patient with Waldenström's macroglobulinemia, and this inspired …

Acute-phase response factor (APRF) is a transcription factor that blnds to the Interfeukln-6
(IL-@-responsive elements identlfled In the promoters of various acutephase protein genes …

Ten years have passed since the molecular cloning of interleukin 6 (IL-6) in 1986. IL-6 is a
typical cytokine, exhibiting functional pleiotropy and redundancy. IL-6 is involved in the …

It has been reported that soluble interleukin (IL)-6 receptor (sIL-6R) is detected in the serum
of healthy individuals and its level is increased in patients with multiple myeloma and human …

Interleukin (IL)-4 is the most potent factor that causes naive CD4+ T cells to differentiate to
the T helper cell (Th) 2 phenotype, while IL-12 and interferon γ trigger the differentiation of …