Reprogramming of tumor-associated macrophages with anticancer therapies: radiotherapy versus chemo-and immunotherapies

G Genard, S Lucas, C Michiels - Frontiers in immunology, 2017 - frontiersin.org
Tumor-associated macrophages (TAMs) play a central role in tumor progression, metastasis,
and recurrence after treatment. Macrophage plasticity and diversity allow their classification …

Ionizing radiation-induced immune and inflammatory reactions in the brain

K Lumniczky, T Szatmári, G Sáfrány - Frontiers in immunology, 2017 - frontiersin.org
Radiation-induced late brain injury consisting of vascular abnormalities, demyelination,
white matter necrosis, and cognitive impairment has been described in patients subjected to …

Microglia drive transient insult-induced brain injury by chemotactic recruitment of CD8+ T lymphocytes

Z Shi, P Yu, WJ Lin, S Chen, X Hu, S Chen, J Cheng… - Neuron, 2023 - cell.com
The crosstalk between the nervous and immune systems has gained increasing attention for
its emerging role in neurological diseases. Radiation-induced brain injury (RIBI) remains the …

Anti-CD47 Treatment Stimulates Phagocytosis of Glioblastoma by M1 and M2 Polarized Macrophages and Promotes M1 Polarized Macrophages In Vivo

M Zhang, G Hutter, SA Kahn, TD Azad, S Gholamin… - PloS one, 2016 - journals.plos.org
Tumor-associated macrophages (TAMs) represent an important cellular subset within the
glioblastoma (WHO grade IV) microenvironment and are a potential therapeutic target. TAMs …

Sexual dimorphism in the inflammatory response to traumatic brain injury

S Villapol, DJ Loane, MP Burns - Glia, 2017 - Wiley Online Library
The activation of resident microglial cells, alongside the infiltration of peripheral
macrophages, are key neuroinflammatory responses to traumatic brain injury (TBI) that are …

Microglia in cancer therapy-related cognitive impairment

EM Gibson, M Monje - Trends in neurosciences, 2021 - cell.com
Millions of cancer survivors experience a persistent neurological syndrome that includes
deficits in memory, attention, information processing, and mental health. Cancer therapy …

CCR2 antagonism alters brain macrophage polarization and ameliorates cognitive dysfunction induced by traumatic brain injury

JM Morganti, TD Jopson, S Liu, LK Riparip… - Journal of …, 2015 - Soc Neuroscience
Traumatic brain injury (TBI) is a major risk factor for the development of multiple
neurodegenerative diseases. With respect to the increasing prevalence of TBI, new …

Microglia activation states and cannabinoid system: Therapeutic implications

M Mecha, FJ Carrillo-Salinas, A Feliú, L Mestre… - Pharmacology & …, 2016 - Elsevier
Microglial cells are recognized as the brain's intrinsic immune cells, mediating actions that
range from the protection against harmful conditions that modify CNS homeostasis, to the …

Pathophysiological responses in rat and mouse models of radiation-induced brain injury

L Yang, J Yang, G Li, Y Li, R Wu, J Cheng… - Molecular neurobiology, 2017 - Springer
The brain is the major dose-limiting organ in patients undergoing radiotherapy for assorted
conditions. Radiation-induced brain injury is common and mainly occurs in patients …

Nuclear receptors license phagocytosis by trem2+ myeloid cells in mouse models of Alzheimer's disease

JC Savage, T Jay, E Goduni, C Quigley… - Journal of …, 2015 - Soc Neuroscience
Alzheimer's disease (AD) is characterized by a robust inflammatory response elicited by the
accumulation and subsequent deposition of amyloid (Aβ) within the brain. The brain's …