Disease-specific tau filaments assemble via polymorphic intermediates
Intermediate species in the assembly of amyloid filaments are believed to play a central role
in neurodegenerative diseases and may constitute important targets for therapeutic …
in neurodegenerative diseases and may constitute important targets for therapeutic …
Accurate prediction of protein structural flexibility by deep learning integrating intricate atomic structures and Cryo-EM density information
The dynamics of proteins are crucial for understanding their mechanisms. However,
computationally predicting protein dynamic information has proven challenging. Here, we …
computationally predicting protein dynamic information has proven challenging. Here, we …
RNA sample optimization for cryo-EM analysis
RNAs play critical roles in most biological processes. Although the three-dimensional (3D)
structures of RNAs primarily determine their functions, it remains challenging to …
structures of RNAs primarily determine their functions, it remains challenging to …
[HTML][HTML] Single particle cryo-EM map and model validation: It's not crystal clear
GC Lander - Current Opinion in Structural Biology, 2024 - Elsevier
Highlights•Single particle cryo-EM structure validation is an area of much-needed
development, and has seen significant recent advances.•The reported resolution of a single …
development, and has seen significant recent advances.•The reported resolution of a single …
Heteromeric amyloid filaments of ANXA11 and TDP-43 in FTLD-TDP type C
D Arseni, T Nonaka, MH Jacobsen, AG Murzin… - Nature, 2024 - nature.com
Neurodegenerative diseases are characterized by the abnormal filamentous assembly of
specific proteins in the central nervous system. Human genetic studies have established a …
specific proteins in the central nervous system. Human genetic studies have established a …
A structural rationale for reversible vs irreversible amyloid fibril formation from a single protein
Reversible and irreversible amyloids are two diverging cases of protein (mis) folding
associated with the cross-β motif in the protein folding and aggregation energy landscape …
associated with the cross-β motif in the protein folding and aggregation energy landscape …
A disease resistance protein triggers oligomerization of its NLR helper into a hexameric resistosome to mediate innate immunity
NRCs are essential helper NLR (nucleotide-binding domain and leucine-rich repeat)
proteins that execute immune responses triggered by sensor NLRs. The resting state of …
proteins that execute immune responses triggered by sensor NLRs. The resting state of …
Structural switch in acetylcholine receptors in developing muscle
During development, motor neurons originating in the brainstem and spinal cord form
elaborate synapses with skeletal muscle fibres. These neurons release acetylcholine (ACh) …
elaborate synapses with skeletal muscle fibres. These neurons release acetylcholine (ACh) …
Structure-based design of a soluble human cytomegalovirus glycoprotein B antigen stabilized in a prefusion-like conformation
MR Sponholtz, PO Byrne, AG Lee… - Proceedings of the …, 2024 - pnas.org
Human cytomegalovirus (HCMV) glycoprotein B (gB) is a class III membrane fusion protein
required for viral entry. HCMV vaccine candidates containing gB have demonstrated …
required for viral entry. HCMV vaccine candidates containing gB have demonstrated …
An image processing pipeline for electron cryo‐tomography in RELION‐5
Electron tomography of frozen, hydrated samples allows structure determination of
macromolecular complexes that are embedded in complex environments. Provided that the …
macromolecular complexes that are embedded in complex environments. Provided that the …